Abstract: With the improvement of people’s living standard, huge changes in the dietary structure have taken place. Increasing proportion of fats in the diet is harmful for human health by inducing blood lipid metabolism disorder and oxidative stress and impairing the intestinal flora balance. In the present study, a mouse model of diet-induced lipid metabolism disorder was established to explore the effects of macronutritional components (protein, starch and flavonoids) of tartary buckwheat on blood lipids, liver lipids and redox capacity in mice and to investigate the relationship between physio-biochemical indexes and antioxidant activity in liver tissue. The results showed that compared with the high-fat control group, the major nutrient components of tartary buckwheat could decrease fasting blood-glucose level, increase insulin sensitivity index, significantly reduce plasma total cholesterol, triglyceride, low density lipoprotein cholesterol, and arteriosclerosis index (P < 0.05). improve total antioxidant capacity and the activity of catalase and superoxide dismutase (SOD), and decrease the content of malondialdehyde (MDA) in lipid peroxidation products. In summary, the major nutritional components of buckwheat have multiple functions including regulating blood lipids, reducing hepatomegaly, improving antioxidant capacity and preventing lipid metabolism disorder, thereby restraining blood lipid disorder and oxidative stress in tissues.

Key words: tartary buckwheat, blood lipid metabolism, oxidative stress