Functional significance and structure-activity relationship of food-derived PTP1B inhibitors

Abstract

Abstract: Protein tyrosine phosphatase 1B (PTP1B), a potential target for the treatment of diabetes and obesity, plays a key negative regulatory role in insulin and leptin signaling pathways. Natural products with the diversity structures can affect different targets and pathways to exert their unique preventive and therapeutic effects on diabetes or its complications. Various food-derived natural products have been reported for their PTP1B inhibitory activity in recent years. This article mainly overviews the mechanism of action of PTP1B and the research progress of food-derived natural PTP1B inhibitors, which will hopefully provide a theoretical rationale for further research on PTP1B inhibitors and the development of new PTP1B inhibitors or hypoglycemic functional foods.

Key words: food-derived, natural compounds, type 2 diabetes, PTP1B inhibitor

CLC Number:

TS201.4

Mei-Li BAO. Functional significance and structure-activity relationship of food-derived PTP1B inhibitors[J]. FOOD SCIENCE, 0, (): 0-0.

References

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