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The roles of functional sweetener in the process of obesity

Li-Ping GAN 2, 2, 2, 2, 2, 2, 2   

  • Received:2023-03-10 Revised:2024-02-24 Online:2024-05-15 Published:2024-04-30
  • Contact: Li-Ping GAN E-mail:lpgan@haut.edu.cn

Abstract: Obesity prevalence has been increasing dramatically worldwide. As a metabolic disorder syndrome, obesity is associated with various health issues, and is characterized by excess lipid storage, a large proportion of which is due to excess intake of sugars from food and beverages. Therefore, replacing sugar with low-calorie functional sweeteners or sugar substituents is a popular dietary choice for the prevention and management of obesity. However, the relationship between functional sweeteners and obesity is complex and there is no conclusive evidence on the effect of functional sweeteners on body weight or adiposity metabolism. This outcome may stem from the different type and doses of functional sweeteners, as well as individual differences, including gender, health status, and gut microbial composition. In this review, we discuss the effects of functional sweeteners on energy balance, adiposity metabolism, and gut microbiota in relation to the current research on the effects of functional sweeteners on obesity. We also review the potential mechanisms through which functional sweeteners may influence energy metabolism and gut microbiota and provide a reference for better selection or use of foods and beverages containing functional sweeteners in the future.

Key words: functional sweetener, obesity, energy balance, intestinal microbiota, mechanism

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