• 营养卫生 •

### 植物乳杆菌67干预频次及周期对高脂血症大鼠血脂的影响

1. （扬州大学 江苏省乳品生物技术与安全控制重点实验室，江苏 扬州 225127）
• 出版日期:2020-06-15 发布日期:2020-06-22
• 基金资助:
国家自然科学基金面上项目（31571855）；江苏省高校自然科学研究重大项目（17KJA550004）

### Effect of Lactobacillus plantarum 67 Intervention Frequency and Cycle on Blood Lipids in Rats with Hyperlipidemia

HUANG Yujun, YAO Yao, ZHOU Fan, GU Ruixia

1. (Jiangsu Key Laboratory of Dairy Biological Technology and Safety Control, Yangzhou University, Yangzhou 225127, China)
• Online:2020-06-15 Published:2020-06-22

Abstract: Objective: To explore the effect of probiotic intervention frequency and cycle on blood lipids in hyperlipidemic rats. Methods: A rat model of hyperlipidemia was established through feeding a high fat diet for 4 consecutive weeks, and two intervention groups were designed by using the probiotic Lactobacillus plantarum (Lp) 67 combined with intermittent fasting, a dietary strategy for treating obese people: intragastric administration with an Lp 67 suspension of 108 CFU/mL 5 times weekly plus physiological saline for the remaining 2 days, and administration with the same suspension every other day weekly plus physiological saline for the remaining days. Body mass was weighed during the intervention period and visceral organ indexes after 4, 6, and 8 weeks of intervention and the serum levels of total cholesterol, total triglyceride, high-density liptein cholesterol and low-density liptein cholesterol were measured. The two intervention groups were compared with the 7-day continuous intervention, control and model groups in terms of all these parameters. Results: Compared with the model group, all three intervention treatments could effectively control blood lipids in rats, and there were significant differences among these intervention groups (P＜0.05). In general, Lp 67 intervention 5 times a week for 6 consecutive weeks was the most effective in improving the blood lipid profile. Conclusion: The frequency and cycle of probiotic intervention have significant effects on improving blood lipids in hyperlipidemic rats.