食品科学 ›› 2012, Vol. 33 ›› Issue (13): 259-262.doi: 10.7506/spkx1002-6630-201213055

• 营养卫生 • 上一篇    下一篇

枸杞多糖对2 型糖尿病病人的短期干预

蔡慧珍,刘福康,芦慧霞,郭斐,胡丽杰,韩超,孙桂菊   

  1. 1.东南大学公共卫生学院,环境医学工程教育部重点实验室 2.宁夏医科大学公共卫生学院 3.东南大学附属中大医院 4. 南京市江浦人民医院 5.上海善力健生物科技有限公司
  • 出版日期:2012-07-15 发布日期:2012-07-27
  • 基金资助:
    国家自然科学基金项目(30872119);高等学校博士学科点专项科研基金项目(20100092110039)

Short-Term Intervention of Lycium barbarum Polysaccharide on Type 2 Diabetes

CAIHui-zhen,LIUFu-kang,LUHui-xia,GUOFei,HULi-jie,HANChao,SUNGui-ju   

  1. (1. Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, College of Public Health, Southeast University, Nanjing 210009, China;2. College of Public Health, Ningxia Medicine University, Yinchuan 750004, China;3. Zhongda Hospital Affiliated, Southeast University, Nanjing 210009, China;4. Nanjing Jiangpu People , s Hospital, Nanjing 211800, China; 5. Sonergy Laboratories Shanghai Co. Ltd., Shanghai 200120, China)
  • Online:2012-07-15 Published:2012-07-27

摘要: 目的:研究枸杞多糖(LBP)对2型糖尿病人血糖及其胰岛素抵抗相关细胞因子的作用。方法:采用1:1匹配法选取年龄相差不超过5岁,糖尿病病程相差不超过5年,服药类型和剂量相近的糖尿病患者,分别服用LBP胶囊(300mg/d,持续3个月)和安慰剂进行干预和统计分析。结果:干预前后两组人群的血糖、肿瘤坏死因子α(TNF-α)变化有统计学差异。两组的瘦素、白细胞介素-6(IL-6)、脂联素和C反应蛋白变化无统计学差异。结论:LBP能够通过抑制TNF-α水平缓解2型糖尿病患者的胰岛素抵抗,从而降低血糖。

关键词: 枸杞多糖, 2型糖尿病, 血糖

Abstract: Objective: To study the effect of Lycium barbarum polysaccharide (LBP) on hypoglycemic activity and cytokine in type 2 diabetic patients. Methods: The 1:1 matching method was used to select subjects according to their age (difference no more than 5 years old), duration of diabetes (difference no more than 5 years) and drug type and doses. LBP or placebo was provided by 300 mg/d for 3 consecutive months. Results: Fasting serum glucose and TNF-α had a significant difference between two groups after administration for 3 months. However, no significant difference was observed in leptin, interleukin 6 (IL-6), adiponectin and C reactive protein. Conclusion: LBP has the functions of decreasing serum glucose and reducing TNF-α in type 2 diabetic patients.

Key words: Lycium barbarum polysaccharide, type 2 diabetes, glucose

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