食品科学 ›› 2013, Vol. 34 ›› Issue (11): 316-320.doi: 10.7506/spkx1002-6630-201311067

• 专题论述 • 上一篇    下一篇

生物活性物质壳寡糖对阿尔茨海默病防治作用研究进展

张 姣,戴雪伶,姜招峰   

  1. 北京联合大学 生物活性物质与功能食品北京市重点实验室,功能食品科学技术研究院,北京 100191
  • 收稿日期:2012-03-04 修回日期:2013-05-06 出版日期:2013-06-15 发布日期:2013-06-03
  • 通讯作者: 姜招峰 E-mail:zhaofeng@buu.edu.cn
  • 基金资助:

    国家自然科学基金面上项目;北京市属高等学校人才强教计划高层次人才资助项目

Research Progress in Functions of Bioactive Chitooligosaccharides in Prevention and Treatment of Alzheimer’s Disease

ZHANG Jiao,DAI Xue-ling,JIANG Zhao-feng   

  1. Beijing Key Laboratory of Bioactive Substances and Functional Foods, Research Institute for Science and Technology of Functional Food, Beijing Union University, Beijing 100191, China
  • Received:2012-03-04 Revised:2013-05-06 Online:2013-06-15 Published:2013-06-03

摘要:

阿尔茨海默病是一种以神经元细胞大量凋亡,神经元细胞内神经纤维缠结以及神经元细胞外老年斑形成为主要病理学特征的中枢神经退行性疾病。壳寡糖,又名为β-1,4-寡聚-葡萄糖胺,是唯一带正电的天然碱性多糖,具有多种生物活性。壳寡糖对阿尔茨海默病的防治有重要意义,主要在保护神经元细胞、抑制Tau蛋白异常磷酸化、抑制β-分泌酶活性、抗氧化、螯合铜离子、抑制乙酰胆碱酯酶等方面发挥作用。本文结合阿尔茨海默病发生机制及壳寡糖特性,综述近年来壳寡糖在防治阿尔茨海默病中的研究进展,旨在为壳寡糖在保健食品中的开发与利用提供一定的参考。

关键词: 壳寡糖, 阿尔茨海默病, 神经保护

Abstract:

Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which is characterized by the loss of
neuronal cells, intracellular neurofibrillar tangles and extracellular senile plaques. Chitooligosaccharide, also termed β-1,4-
oligomerization-glucosamine, is the alkaline oligosaccharide with multiple biological activities. Chitooligosaccharide
plays an important role in the prevention and treatment of AD by protecting neuronal cells from death, suppressing
hyperphosphorylation of tau, reducing the activity of β-secretase, antioxidation, chelating copper ions, and suppressing
the activity of acetylcholinesterase. In this paper, we have reviewed the recent research progress of chitooligosaccharide
on prevention and treatment of AD, which will provide a theoretical reference for the development and utilization of
chitooligosaccharide in health foods.

Key words: chitooligosaccharide;Alzheimer&rsquo, s disease;neuroprotective effects

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