食品科学 ›› 2023, Vol. 44 ›› Issue (23): 332-352.doi: 10.7506/spkx1002-6630-20221209-098

• 专题论述 • 上一篇    下一篇

植物源天然产物干预丙烯酰胺神经毒性的研究进展

张梦玉, 张彦青, 房雷雷, 解军波, 魏英豪   

  1. (1.天津商业大学生物技术与食品科学学院,天津 300134;2.天津中医药大学中药学院,天津 300073)
  • 出版日期:2023-12-15 发布日期:2024-01-02
  • 基金资助:
    天津市“131”创新型人才团队项目(201927)

Research Progress on Intervention of Natural Products from Plants in Neurotoxicity of Acrylamide

ZHANG Mengyu, ZHANG Yanqing, FANG Leilei, XIE Junbo, WEI Yinghao   

  1. (1. School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China;2. School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300073, China)
  • Online:2023-12-15 Published:2024-01-02

摘要: 丙烯酰胺(acylamide,ACR)是食品中常见的一种毒性物质,会对人体各器官和系统尤其是神经系统造成严重的损害。目前,尚未有合适的预防和治疗ACR神经毒性的措施。近年来,具有高食用安全性、强抗氧化活性、低成本等优势的植物源天然产物被报道能够干预ACR诱导的神经毒性。本文主要介绍了ACR的神经毒性及干预这种毒性的植物源天然产物,并在此基础上总结了植物源天然产物干预ACR神经毒性的作用机制,以期为多途径、多靶点治疗ACR神经毒性和天然产物的开发及应用提供理论参考和研究思路。

关键词: 天然产物;丙烯酰胺;神经毒性;干预

Abstract: Acrylamide (ACR) is a common toxic substance in foods, which can cause serious damage to human organs and systems, especially the nervous system. At present, there are no appropriate measures to prevent and treat ACR neurotoxicity. In recent years, it has been reported that some natural plant products with high safety for consumption, strong antioxidant activity and low cost can intervene in ACR-induced neurotoxicity. This paper mainly introduces the neurotoxicity of ACR, natural plant products that can intervene in ACR neurotoxicity, and the underlying mechanism of action in order to provide a theoretical reference and research ideas for the treatment of ACR neurotoxicity in multiple ways and though multiple targets, as well as the development and application of natural products against ACR neurotoxicity.

Key words: natural products; acrylamide; neurotoxicity; intervention

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