食品科学 ›› 2007, Vol. 28 ›› Issue (10): 507-510.

• 营养卫生 • 上一篇    下一篇

L-苹果酸对老年大鼠组织中转氨酶活性的影响

 吴军林, 吴清平, 张菊梅   

  1. 广东省微生物研究所广东省菌种保藏与应用重点实验室; 广东省微生物研究所广东省菌种保藏与应用重点实验室 广东广州510070; 广东广州510070;
  • 出版日期:2007-10-15 发布日期:2011-11-22

Effects of L-malate on Activities of Transferases in Different Tissues of Aged Rats

 WU  Jun-Lin, WU  Qing-Ping, ZHANG  Ju-Mei   

  1. Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou 510070, China
  • Online:2007-10-15 Published:2011-11-22

摘要: L-苹果酸(malicacid)是生物体代谢过程中产生的重要有机酸,在线粒体产生能量物质ATP的代谢过程中起到重要作用。为探讨苹果酸对老年机体不同组织中酶活性的影响,将实验动物SD大鼠随机分为4组,每组6只,连续灌胃苹果酸30d,测定大鼠体内丙氨酸氨基转移酶(ALT)及天冬氨酸氨基转移酶(AST)活性。发现老年大鼠肝脏中ALT及AST活性低于年轻对照大鼠,苹果酸可提高老年大鼠肝脏中ALT活性41.98%,提示苹果酸可改善老年肝脏酶代谢能力,有利于提高新陈代谢。

关键词: L-苹果酸, 转氨酶, 丙氨酸氨基转移酶, 天冬氨酸氨基转移酶

Abstract: L-malate, an important organic acid on the process of metabolism, plays an important role in generating mitochondria ATP(adenosine triphosphate). To investigate the effects of L-malate on activities of ALT (alanine aminotransferase) and AST (aspartate aminotransferase) in different tissues of aged rats, Sprague-Dawley male rats were randomly divided into 4 groups, each group consisting of 6 animals. L-malate was orally administrated via intragastric canula for 30 days, then the rats were sacrificed and the liver and heart were removed to determine the activities of ALT and AST. Activities of ALT and AST in liver of aged rats decreased compared with control young rats. The activities of ALT in liver of aged rats were enhance (p<0.05) 41.98% by L-malate administration. Our data indicate that enzyme metabolism of liver in aged rats was strengthened by dietary supplementation with L-malate.

Key words: L-malate, alanine aminotransferase, aspartate aminotransferase, aminotransferase