食品科学 ›› 2007, Vol. 28 ›› Issue (10): 510-513.

• 营养卫生 • 上一篇    下一篇

除草剂百草枯对大鼠及胎儿的毒性研究

 权伍荣, 郭环宇, 任大勇, 沈明浩   

  1. 延边大学农学院食品科学系; 吉林农业大学食品科学与工程学院; 吉林农业大学食品科学与工程学院 吉林龙井133400; 吉林长春130118;
  • 出版日期:2007-10-15 发布日期:2011-11-22

Toxic Effect of PQ on Rats and Embryo

 QUAN  Wu-Rong, GUO  Huan-Yu, REN  Da-Yong, SHEN  Ming-Hao   

  1. 1.Department of Food Science, College of Agronomy, Yanbian University, Longjing 133400, China; 2.College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China
  • Online:2007-10-15 Published:2011-11-22

摘要: 本实验研究了除草剂百草枯对大鼠及其胎儿毒性作用。结果表明,雄性大鼠一次性接1/10LD50、1/5LD50和1/2LD50的百草枯不会引起雄性生殖细胞的突变;百草枯在1/10LD50、1/20LD50和1/40LD50的剂量下不能影响雄性大鼠精子活率的改变和精子畸形率的上升,却可以影响睾丸组织中碱性磷酸酶(AKP或ALP)的活性,对睾丸造成一定程度的损伤;百草枯可导致大鼠胎儿特殊循环系统动脉管(DA)的收缩,对其存在毒性作用,并且动脉管内径与染毒剂量剂量之间存在显著的剂量—效应关系。

关键词: 百草枯, 毒性, 大鼠, 胎儿

Abstract: The toxic effect of PQ on rats and fetus was studied in this paper. The results indicated that PQ cannot induce germinal mutation at the dose of 1/10 LD50, 1/5 LD50 and 1/2 LD50 and also cannot enhance the rat’s spermatic activity ratio or induce gential toxicity on rats at the dose of 1/40 LD50, 1/20 LD50 and 1/10 LD50. But PQ can affect the activity of AKP(ALP) by digestive tract at these doses; PQ can induce contraction of DA of embryo showing that PQ has embryonic toxicity; with the dose increasing, the inner diameter of DA decreasing, indicating that there is dose-reaction relationship between the dose and inner diameter of DA.

Key words: PQ, toxicity, rats, embryo