食品科学 ›› 2007, Vol. 28 ›› Issue (9): 542-545.

• 营养卫生 • 上一篇    下一篇

大鼠体内类姜黄素的组成变化

 王政, 惠伯棣, 裴凌鹏, 张静   

  1. 北京联合大学应用文理学院; 中国中医科学院; 北京联合大学应用文理学院 北京100083; 北京100083; 北京100009;
  • 出版日期:2007-09-15 发布日期:2011-11-22

Variation of Composition of Curcuminoids in Rat Body

 WANG  Zheng, HUI  Bo-Di, PEI  Ling-Peng, ZHANG  Jing   

  1. 1.College of Applied Arts and Science,Beijing Union University,Beijing 100083,China;2.China Academy of Traditional Chinese Medicine,Beijing 100009,China
  • Online:2007-09-15 Published:2011-11-22

摘要: 类姜黄素主要包括姜黄素、去甲氧基姜黄素及去二甲氧基姜黄素三种同系物。目的:探索类姜黄素在大鼠体内代谢中的组成变化。方法:姜黄根萃取物灌喂雄性SD大鼠,2h后收集血和肝脏,24h内收集粪便。应用C30-HPLC-PDA,测定和比较根萃取物、血清、肝脏和粪便中的类姜黄素组成。结果:粪便中姜黄素的组成与姜黄根中的一致,而血清和肝脏中的姜黄素比例显著上升。结论:姜黄素的比例在血清中开始上升。姜黄素是进入体内的主要组分。

关键词: 类姜黄素, 吸收

Abstract: Curcuminoids mainly include three homologues:curcumin,demethoxy curcumin and bisdemethoxy curcumin.Objective:This study aims at the exploration of variation of the composition of curcuminoidsin rat body.Methods:Male SD rat was orally administrated with an extract from Curcuma Longa L root.Serum and liver were collected after 2 hour.Feces were collected for 24 hours.Their curcuminoid composition(CC)was assessed by C30-HPLC-PDA.Results:The CC from feces was similar to that from the root extract while curcumin ratio from homogenized liver tissue and serum was significantly higher.Conclusion:An increased curcumin ratio took place in serum.Curcumin was major fraction to access rat body.

Key words: curcuminoids, absorption