食品科学 ›› 2025, Vol. 46 ›› Issue (18): 1-13.doi: 10.7506/spkx1002-6630-20250128-206

• 肌骨健康食品专栏 •    下一篇

肌少症发病机制及天然活性成分的缓解作用与应用研究进展

丁晓宇,贾磊,刘回民,刘景圣   

  1. (吉林农业大学食品科学与工程学院,小麦和玉米深加工国家工程研究中心,吉林?长春 130118)
  • 出版日期:2025-09-25 发布日期:2025-08-19
  • 基金资助:
    “十四五”国家重点研发计划项目(2022YFF1100205)

Research Progress on the Pathogenesis of Sarcopenia and the Mechanism of Action and Application of Natural Active Components in Alleviating and Preventing This Disease

DING Xiaoyu, JIA Lei, LIU Huimin, LIU Jingsheng   

  1. (National Engineering Research Center for Wheat and Corn Processing, College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China)
  • Online:2025-09-25 Published:2025-08-19

摘要: 肌少症是一种与年龄相关的进行性、全身性骨骼肌疾病。随着全球老龄化程度的加剧,肌少症已成为影响老年人健康的重要问题。研究表明,多酚类、黄酮类、生物碱类等天然活性成分可以通过调控蛋白质稳态、改善线粒体功能、抑制炎症反应与缓解神经肌肉接头病变在缓解肌少症进程中发挥重要作用。然而,由于天然活性成分种类繁多且分子机制复杂,相关应用仍面临挑战。因此,本文结合肌少症的发病机制,系统综述了天然活性成分在体内外实验中的作用机制,并总结了其在相关临床研究中的进展,旨在为天然活性成分在肌少症防治中的开发与应用提供科学参考。

关键词: 天然活性成分;肌少症;蛋白质稳态;线粒体功能;临床研究

Abstract: Sarcopenia is a progressive, systemic skeletal muscle disorder associated with aging. With the increase in the global aging population, sarcopenia has become a significant health issue for the elderly. Studies have shown that natural bioactive compounds, such as polyphenols, flavonoids, and alkaloids, play an important role in alleviating the progression of sarcopenia by regulating protein homeostasis, improving mitochondrial function, inhibiting inflammation, and mitigating neuromuscular junction (NMJ) degeneration. However, due to the diversity of natural bioactive compounds and the complexity of their molecular mechanisms, their application still faces some challenges. Therefore, this article systematically reviews the literature on the pathogenesis of sarcopenia, the mechanism of action of natural bioactive compounds in alleviating sarcopenia, and their application for preventing this disease, aiming to provide scientific references for the development and application of natural bioactive compounds in the prevention and treatment of sarcopenia.

Key words: natural bioactive compounds; sarcopenia; protein homeostasis; mitochondrial function; clinical research

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