食品科学 ›› 2009, Vol. 30 ›› Issue (21 ): 409-415.doi: 10.7506/spkx1002-6300-200921096

• 专题论述 • 上一篇    下一篇

生物活性肽对肠黏膜免疫调节作用的研究进展

贾玉臣,陈庆森*   

  1. 天津市食品生物技术重点实验室,天津商业大学生物技术与食品科学学院
  • 收稿日期:2009-07-01 出版日期:2009-11-01 发布日期:2010-12-29
  • 通讯作者: 陈庆森 E-mail:chqsen@tjcu.edu.cn
  • 基金资助:

    国家自然科学基金项目(30771524)

Research Progress in Immune Regulation of Bioactive Peptides on Gut Mucosa

JIA Yu-chen,CHEN Qing-sen*   

  1. Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science,Tianjin University of Commerce,
    Tianjin 300134, China
  • Received:2009-07-01 Online:2009-11-01 Published:2010-12-29
  • Contact: CHEN Qing-sen E-mail:chqsen@tjcu.edu.cn

摘要:

大量研究已证实生物活性肽是一类对机体有许多重要生理功能的物质,对拥有巨大表面积的肠黏膜有着重要的免疫调节作用。本文首先概括生物活性肽的研究现状;在从肠黏膜系统组成及其免疫机制的角度,结合前期的研究工作,就生物活性肽对SIgA、Th 细胞及其细胞因子以及免疫信号途径影响的相关研究进行介绍。同时根据国外学者近期研究的成果,提出研究生物活性肽与机体免疫作用关系的发展趋势。

关键词: 生物活性肽, 肠黏膜, SIgA, 细胞因子, 免疫信号途径

Abstract:

Numerous studies have reported that bioactive peptides have many physiological functions to human including immune regulation on gut mucosa with tremendous surface area. Current research progress of bioactive peptides is reviewed here. Effects of bioactive peptides on SIgA, Th cells, cytokines and immune signaling pathways are discussed on the basis of structures and immune mechanisms of gut mucosa. The future development prospects of bioactive peptides are proposed.

Key words: bioactive peptide, gut mucosa, SigA, cytokine, immune signaling pathway

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