食品科学 ›› 2007, Vol. 28 ›› Issue (11): 513-515.

• 营养卫生 • 上一篇    下一篇

茶多酚对血浆脂蛋白氧化的抑制作用

 尹学哲, 全吉淑, 金泽武道   

  1. 延边大学医学院; 日本东北食效科学研究所 吉林延吉133000; 吉林延吉133000; 本州青森030-0842;
  • 出版日期:2007-11-15 发布日期:2011-11-22

Inhibitory Effects of Tea Polyphenol on Oxidative Modification of Human Plasma Lipoproteins

 YIN  Xue-Zhe, QUAN  Ji-Shu, JIN  Ze-Wu-Dao   

  1. 1.Medical College, Yanbian University, Yanji 133000, China; 2.Institute of Food Factors Science for Health, Aomori 030-0842, Japan
  • Online:2007-11-15 Published:2011-11-22

摘要: 14名健康受试者空腹饮用茶多酚后抽取静脉血,采用序列超速离心法分离血浆极低密度脂蛋白(VLDL)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL),并观察各血浆脂蛋白过氧化程度以及氧化易感性的变化。结果表明:茶多酚饮用后受试者VLDL、LDL和HDL过氧化脂质水平明显降低;在体外进行氧化修饰时,LDL氧化延滞时间明显延长,提示LDL氧化易感性下降。茶多酚可降低脂蛋白过氧化程度和增强LDL抗氧化修饰能力,因此能够起到防治心血管疾病的积极作用。

关键词: 茶多酚, 脂质过氧化, 氧化易感性, 脂蛋白

Abstract: Very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) were isolated from fast plasma by sequential ultracentrifugation before and after 14 healthy subjects were administered tea polyphenol, so degrees of peroxidization and susceptibilities of lipoproteins to oxidation were then investigated. The results showed that the lipid peroxides of VLDL, LDL and HDL are significantly decreased after the intake tea polyphenol of the lag phase of LDL oxidation curve inv itro is noticeably prolonged, indicating a reduced susceptibility to oxidation. It is suggested that tea polyphenol used to decrease the peroxidizability of lipoproteins and promote resistance to LDL oxidation, as well may be useful in prevention and treatment of cardiovascular diseases.

Key words: tea polyphenol, lipid peroxidation, oxidative susceptibility, lipoproteins