关键词: 掌叶覆盆子, 高血脂

Abstract: Objective: To study the effect of Hubei Rubus chingii Hu leaf on serum lipid metabolism in hyperlipidemia rats and adults. Methods: In hyperlipidemia animal models, according to the serum TC, TG and HDL-C concentrations levels, 50 rats were randomly divided into five groups: control group, hyperlipidemia model group, and 0.5, 1.0, 2.0 g/kg bw dose groups. Control group was fed with basic feed and other groups were fed with high percent lipid feed. Dose groups were ingested with Rubus chingii Hu water soluble extract for 30 days, and control and model groups ingested with water, then the serum TC, TG and HDL- C concentrations were determined. In human intervention trials, 112 hyperlipidemia adult volunteers were selected and ran- domly divided into two groups, namely experiment group and control group, according to their serum TC, TG levels, age, gender and diet etc. Experiment adults group were given Rubus chingii Hu leaf drinking in the dose of 3 times per day and 2g per time without changing daily custom and diet, while control group adults were not given any intervention trematmeat. 30 days later, serum TC, TG and HDL-C levels were determined. Results: In animal study, compared with control, serum TC, TG levels of 1.0, 2.0 g/kg bw dose of Rubus chingii Hu leaf groups decrease significantly (p<0.05) after 30 days of treatments. At the end of human trial, comparison with control, serum TC, TG levels of experiment groups decrease significantly(p<0.05). whereas the rate of effective lowering lipid level is 80.4% in experiment group at the end of trials. Conclusion: Hubei Rabus chingii Hu leaves show significant effects of decceasing regulating serum lipid levels in rats and human adults as well.

Key words: Rubus chingii Hu, serum lipid