食品科学 ›› 2009, Vol. 30 ›› Issue (21): 348-350.doi: 10.7506/spkx1002-6300-200921081

• 营养卫生 • 上一篇    下一篇

木樨草素对高血脂大鼠抗氧化能力的影响

任 鹏,贺新生,刘 超   

  1. 西南科技大学生命科学与工程学院
  • 收稿日期:2008-11-17 修回日期:2009-06-26 出版日期:2009-11-01 发布日期:2010-12-29
  • 通讯作者: 任鹏 E-mail:renpeng@swust.edu.cn

Effect of Luteolin on Blood Lipid Level and Antioxidant Capability in Hyperlipidemic Rats

REN Peng,HE Xin-sheng,LIU Chao   

  1. College of Life Science and Engineering, Southwest University of Science and Technology,Mianyang 621010, China
  • Received:2008-11-17 Revised:2009-06-26 Online:2009-11-01 Published:2010-12-29
  • Contact: REN Peng E-mail:renpeng@swust.edu.cn

摘要:

目的:探讨木樨草素对高血脂大鼠血清抗氧化功能的作用及其可能机制。方法:建立高血脂大鼠模型,观察给药后血脂水平和血清T-AOC、SOD、CAT 和MDA 变化。结果:各剂量药物组血清中TC、TG 和MDA水平显著低于模型对照组(P < 0.05),HDL-C 水平显著高于模型对照组(P < 0.05),T-AOC、SOD、CAT 活性显著高于模型对照组(P < 0.05)。结论:木樨草素可提高高血脂大鼠血清抗氧化酶活性,降低脂质过氧化程度。

关键词: 木樨草素, 高血脂, 抗氧化能力

Abstract:

High, medium and low doses of luteolin were administered to high fat diet-induced hyperlipidemic rat model established in adult Sprague-Dawley rats for investigating its effects on the levels of blood lipid and antioxidant indexes in hyperlipidemia rats, including MDA content, T-AOC, and SOD and CAT activities. Results showed that all three dose groups exhibited significantly lower levels of TC, TG and MDA and higher levels of HDL-C, T-AOC, SOD and CAT when compared with model control group (P < 0.05). In conclusion, luteolin might contribute to improve the serum antioxidant capability and reduce the lipid peroxidative damage in hyperlipidemic rats.

Key words: luteolin, hyperlipidemia, antioxidant capability

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