食品科学 ›› 2011, Vol. 32 ›› Issue (23): 285-288.doi: 10.7506/spkx1002-6630-201123057

• 营养卫生 • 上一篇    下一篇

平贝母多糖对D-半乳糖诱导衰老模型小鼠的抗氧化作用

刘春红1,金钟斗2,韩宝瑞3,*   

  1. 1.长春大学特殊教育学院 2.东方大学院大学校 3.吉林农业大学发展学院
  • 出版日期:2011-12-15 发布日期:2011-12-21
  • 基金资助:
    吉林省教育厅“十二五”科学技术研究项目(2011 第210 号); 吉林省教育厅“十一五”科学技术研究项目(2010 第511 号)

Antioxidant Activity of Polysaccharide FUP-1 from Fritillaria ussuriensis Maxim in D-Galactose-induced Aging Mouse Model

LIU Chun-hong1,KIM Jong-du2,HAN Bao-rui3,*   

  1. (1. Special Education College of Changchun University, Changchun 130022, China;2. Dongbang Graduate University, Seoul 136823, Korea;3. Development College of Jilin Agricultural University, Changchun 130600, China)
  • Online:2011-12-15 Published:2011-12-21

摘要: 为了探讨平贝母多糖对D-半乳糖诱导衰老模型小鼠的体内抗氧化作用,采用颈背皮下注射D-半乳糖(500mg/(kg ·d))建立亚急性衰老小鼠模型,通过对各组小鼠一般体征、脏器指数、血清或肝组织抗氧化酶活性及脑组织单胺氧化酶(MAO)活力的比较分析,全面评价平贝母多糖FUP-1的抗氧化衰老作用。结果表明:与模型组相比平贝母多糖FUP-1能显著降低D-半乳糖诱导衰老小鼠肝脏组织中丙二醛(MDA)含量(P<0.05),提高肝组织中总抗氧化能力(T-AOC)、显著提高肝组织中谷胱甘肽过氧化物酶(GSH-Px)活性和血清超氧化物歧化酶(SOD)活性(P<0.05),同时降低脑组织中MAO活力。提示平贝母多糖FUP-1具有一定的延缓衰老作用,其作用可能与其提高抗氧化酶活性和抗脂质过氧化有关。

关键词: 平贝母, 多糖, 抗衰老, 抗氧化

Abstract: To investigate the antioxidant activity of polysaccharide isolated from Fritillaria ussuriensis Maxim (FUP-1) on senescent mice induced by D-galactose, mice were induced senescence by consecutive injection of D-galactose (500mg/kg/d)) once daily for 7 weeks and fed Vitamin E and different doses of F. ussuriensis polysaccharide. Antioxidant activity in liver and serum, and anti-aging activity in brain were measured. The results showed that the F. ussuriensis polysaccharide could significantly improve general appearance of the aging model mice. In comparison with the aging model group, the activities of superoxide dismutase (SOD) in serum, total anti-oxidative capacity (T-AOC) and glutathione peroxidase (GSH-Px) activities in liver of the two FUP-1 groups were increased and the malondialdehyde (MDA) levels in liver were decreased. FUP-1 treatment significantly decreased monoamine oxidase (MAO) activities of brain in D-galactose treated mice. In conclusion, FUP-1 has antioxidant activity on aging model mice and the mechanism may be related to the enhancement of activity of antioxidases and the reduction of lipid peroxidation.

Key words: Fritillaria ussuriensis, polysaccharide, anti-aging, antioxidant

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