Abstract:

In this study, 30 male Wistar rats were randomly divided into the control group (n=10) which was fed basic diet, and the model group (n=20) which was fed high fat diet. After 6 weeks, the model group was randomly divided into 2 subgroups: insulin resistant group (n=10) which continued to receive high fat diet, and Phyllanthus emblica L. extract group (n=10) which was fed high fat diet and administered by gavage with 3.5 g/kg body weight of Phyllanthus emblica L. extract at the same time. After the treatment with Phyllanthus emblica L. extract for 6 weeks, the expression levels of PPARγ in the fat tissue of rats were determined by RT-PCR. The results showed that the high fat diet successfully induces insulin resistance of rats, but the Phyllanthus emblica L. extract significantly improves their insulin resistance. The PPARγ expression of rats in insulin resistance group is slightly higher than that of ratsin the control group, but is significantly lower than that of ratin Phyllanthus emblica L. extract group. In conclusion, the Phyllanthus emblica L. extract can significantly improve insulin resistance, which may be related to the increase of PPARγ mRNA expression.

Key words: insulin resistance, Phyllanthus emblica L. extract, peroxisome prolifemtor-activated receptor γ, adiponectin