Abstract:

Objective: To explore the effect of Ciwujia glycosides on D-galactose-induced subacute intoxicating rats. Methods: Subacute intoxication models of rats were constructed by administering them with 100 mg/(kg bw·d) of D-galactose through intraperitoneal injection. Healthy SD rates were randomly divided into 5 groups of 8 rate each (half female and half male): control group, subacute intoxication model group, and low-, medium- and high-dose-treated groups administered with 3.6, 7.2, and 14.4 g/(kg bw·d) of Ciwujia glycosides by gavage, respectively. After continued administration for 8 weeks, all the rats were sacrificed, and then the thymus index and spleen index were measured and the proliferation capability of T lymphocyte, tissue SOD activity and MDA concentration, and serum interleukin-2 (IL-2) and interleukin-6 (IL-6) concentrations were assayed. Results: Pronounced rises in thymus index, proliferation capability of T lymphocyte, tissue SOD activity and serum IL-2 concentration and falls in tissue MDA concentration and serum IL-6 concentration were observed in Ciwujia glycosides-treated rats in comparison with subacute intoxicating ones. Conclusion: Ciwujia glycosides can effectively scavenge free radicals and improve the immune system in D-galactose induced subacute intoxicating rats.

Key words: Ciwujia glycosides, subacute intoxicating rats, malondialdehyde (MDA), superoxidedismutase (SOD), IL-2, IL-6