Effect of Chinese Wolfberry (Lycium barbarum) Polysaccharides on Number and Distribution of Intraepithelial Lymphocytes and Goblet Cells and IL-2 Expression in Mice

doi:10.7506/spkx1002-6630-201113069

Abstract

Abstract: In order to explore the effect of Lycium barbarum polysaccharides (LBP) on intestinal mucosal barrier function in rats, the number and distribution of intraepithelial lymphocytes (IEL) and goblet cells (GC) in 10 C57BL/J mice were observed by light microscope after oral administration with LBP for a week. The results showed that the number of IEL and GC exhibited an obvious increase and these cells moved towards the inner layer of the small intestine. Meanwhile, the IL-2 expression level in the intestinal mucosa also revealed a significant increase. These studies suggested that LBP could promote the integrity of the small intestinal mucosal barrier structure and improve the immune function.

Key words: Lycium barbarum polysaccharides, mouse, intraepithelial lymphocyte, goblet cell, interleukin-2(IL-2)

CLC Number:

S852.4

CHEN Xian-wei. Effect of Chinese Wolfberry (Lycium barbarum) Polysaccharides on Number and Distribution of Intraepithelial Lymphocytes and Goblet Cells and IL-2 Expression in Mice[J]. FOOD SCIENCE, 2011, 32(13): 318-320.

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Effect of Chinese Wolfberry (Lycium barbarum) Polysaccharides on Number and Distribution of Intraepithelial Lymphocytes and Goblet Cells and IL-2 Expression in Mice

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