Serum Metabonomics Study of Type 2 Diabetic Rats Administrated with Lycium barbarum Polysaccharides

doi:10.7506/spkx1002-6630-201713027

Abstract

Abstract: Gas chromatography-time of flight-mass spectrometry (GC-TOF-MS) was employed for serum metabolite profiling of rats in the control group (NC), type 2 diabetic model group (DM) and Lycium barbarum polysaccharides (LBP group) treatment groups. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used for clustering serum metabolite profiles and finding potential biomarkers. The results demonstrated that the three groups were successfully separated and serum alanine and thymidine were decreased in the DM group as compared to the NC group. One-month intervention with LBP could increase the levels of alanine and thymidine in serum of type 2 diabetic rats, which may be associated with their amino acid and nucleotide metabolism. These results can provide a reference for further study of the hypoglycemic mechanism of LBP.

Key words: Lycium barbarum polysaccharides, type 2 diabetes mellitus, metabonomics, biomarker

CLC Number:

TS201.4

TANG Huali, XIA Hui, WANG Feng, SUN Guiju. Serum Metabonomics Study of Type 2 Diabetic Rats Administrated with Lycium barbarum Polysaccharides[J]. FOOD SCIENCE, 2017, 38(13): 160-166.

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Serum Metabonomics Study of Type 2 Diabetic Rats Administrated with Lycium barbarum Polysaccharides

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