Evaluation on Immune-enhancement Effect of Lactoferrin

doi:10.7506/spkx1002-6630-201011053

FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (11): 244-247.doi: 10.7506/spkx1002-6630-201011053

• Nutrition & Hygiene • Previous Articles Next Articles

Evaluation on Immune-enhancement Effect of Lactoferrin

HU Zhi-he，LI Na，LIU Chuan-guo，PANG Guang-chang，CHEN Qing-sen

Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce,
Tianjin 300134, China

Received:2009-10-14 Revised:2010-03-06 Online:2010-06-01 Published:2010-12-29
Contact: HU Zhi-he E-mail:huzhihe1008@yahoo.com.cn

Abstract

Abstract:

The immune regulatory function of lactoferrin was evaluated according to relevant Chinese national standards for evaluation of immune regulatory functional food. Balb/c mice were chosen to establish an immunodeficiency model. The immunodeficiency mice were orally administered lactoferrin at the dosages of 0.1, 1 mg/mL and 10 mg/mL, respectively. The effect of lactoferrin on immune organ weight, cellular immune function, humoral immune function and monocyte macrophages function were determined. The results showed that lactoferrin exhibited positive reaction within the dosage range of 0.1－10 mg/mL, and the strongest immune effect of lactoferrin was 1 mg/mL. Therefore, it can be concluded that lactoferrin exerts immune regulatory function in a dose-dependent manner.

Key words: lactoferrin, immune enhancement, intragastric administration

CLC Number:

R151.2

HU Zhi-he，LI Na，LIU Chuan-guo，PANG Guang-chang，CHEN Qing-sen. Evaluation on Immune-enhancement Effect of Lactoferrin[J]. FOOD SCIENCE, 2010, 31(11): 244-247.

[1]	SHI Pujie, XU Shiqi, WANG Zhenyu, WU Chao, LU Weihong, DU Ming. Advances in Biological Activity and Functional Mechanism of Peptides from Lactoferrin [J]. FOOD SCIENCE, 2021, 42(7): 267-274.
[2]	ZHAO Xiao, XU Jinghan, CUI Dongying, XU Jinzhao, LIU Yang, TENG Guoxin, XU Xiaoxi. Positive Regulation of Lactoferrin on Gut Micro-Ecology of Rats with Inflammatory Bowel Disease [J]. FOOD SCIENCE, 2021, 42(13): 136-142.
[3]	XIE Yindan, ZHAO Tianyu, XU Yan, REN Haowei, AN Jingjing, LIU Ning. Repairing Effect of Lactoferrin on Triadimefon-Induced Damage of Bone Marrow Mesenchymal Stem Cells [J]. FOOD SCIENCE, 2020, 41(13): 141-147.
[4]	XI Enze, ZHAO Xiao, CUI Dongying, SHENG Xue, LI Menghan, XU Xiaoxi. Effect of in Vitro Digestion Hydrolysate of Bovine Lactoferrin Subjected to Different Pasteurization Treatments on Proliferation of IEC-6 Cells [J]. FOOD SCIENCE, 2019, 40(23): 60-65.
[5]	LIANG Ruihong, HUA Hui, WANG Xuedong, LI Ya, LIU Chengmei, CHEN Jun. Effect of Dynamic High Pressure Microfluidization Treatment Sequence on the Structure and Properties of Pectin-Lactoferrin Complexes [J]. FOOD SCIENCE, 2019, 40(19): 143-148.
[6]	PI Bingbing, ZHAO Xiao, Lü Pingping, PENG Yukai, PAN Lin, XU Xiaoxi. Comparative Study on the Effects of Lactoferrin and Lactoferricin from Different Sources on Proliferation of Mouse Spleen Lymphocytes [J]. FOOD SCIENCE, 2018, 39(13): 184-189.
[7]	LI Xin, WANG Xu, LIU Jiawei, LI Yu, XU Duoxia, CAO Yanping. Influence of Heteroaggregation and Enzymatic Cross-Linking on Rheological Properties of Lactoferrin and Whey Protein Isolate Emulsions [J]. FOOD SCIENCE, 2018, 39(12): 20-25.
[8]	BAO Xiaoyu, CHEN Meixia, WANG Jiaqi, ZHENG Nan. Advances in Bioactive Functions of Milk Proteins [J]. FOOD SCIENCE, 2017, 38(19): 315-323.
[9]	ZHOU Yingshuang, FAN Fengjiao, LIU Meng, YANG Jian, WANG Yun, DU Ming*, ZHANG Lanwei. Interaction Mechanism between Lactoferrin and Other Proteins in Bovine Milk [J]. FOOD SCIENCE, 2015, 36(5): 244-249.
[10]	REN Xiao-dong，CHEN Qing-sen*，LI Jun-jie，ZHOU Li-li，YAN Ya-li. Effect of Administation of CGMP and Lactoferrin by Gavage on Colonization Resistance in the Intestine of Mice [J]. FOOD SCIENCE, 2013, 34(9): 282-286.
[11]	LIU Meng， DU Ming*， KONG Ying-ying，XU Wei-li，SONG Wei， ZHANG Lan-wei. Influence of Heat Treatment on the Osteoblast-promoting Activity of Bovine Lactoferrin [J]. FOOD SCIENCE, 2013, 34(9): 301-304.
[12]	DUN Yao-shan， SHI Yue， PENG Xiao-lu， CHEN Ning*. Action Mechanisms of Sports Nutrition Supplements with Chinese Medicinal Herbs [J]. FOOD SCIENCE, 2013, 34(15): 415-423.
[13]	. Antioxidant Activity of Lactoferrin in vitro [J]. FOOD SCIENCE, 2012, 33(21): 111-113.
[14]	. Effect of Lactoferrin on Th1/Th2 Cell Balance in Peripheral Blood of BALB/C Mice with Food Allergy [J]. FOOD SCIENCE, 2012, 33(21): 308-313.
[15]	. Research Progress in Physio-chemical Characteristics and Osteogenic Activity of Lactoferrin [J]. FOOD SCIENCE, 2012, 33(21): 318-322.

Evaluation on Immune-enhancement Effect of Lactoferrin

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments