Effect of Resveratrol on Antioxidant Status and Insulin Sensitivity in Rat Primary Adipocytes

doi:10.7506/spkx1002-6630-201013060

FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (13): 263-266.doi: 10.7506/spkx1002-6630-201013060

• Nutrition & Hygiene • Previous Articles Next Articles

Effect of Resveratrol on Antioxidant Status and Insulin Sensitivity in Rat Primary Adipocytes

CHEN Si-fan1，XIAO Xin-cai2，SUN Yan-shuang1，ZHENG Lin1，ZHANG Zi-li1，FENG Xiang1,*

1. Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510089, China ；
2. Guangzhou Center for Disease Control and Prevention, Guangzhou 510080, China

Received:2009-12-07 Online:2010-07-01 Published:2010-12-29
Contact: FENG Xiang1,* E-mail:fengx@mail.sysu.edu.cn

Abstract

Abstract:

The effect of resveratrol on the antioxidant status and insulin sensitivity in insulin-resistant rat primary adipocytes was investigated. Rat primary adipocytes were separated and an insulin-resistant model was established using dexamethasone. Glucose consumption as well as SOD and MDA contents in medium and cells treated with resveratrol at varying concentrations was determined. In order to explore the possible mechanisms, the expression and phosphorylation levels of Sirt1, IRS-1, AKT and GLUT4 proteins were examined by western blot. The results indicated that resveratrol increased the glucose consumption and SOD content and suppressed MDA generation in insulin-resistant rat primary adipocytes. Meanwhile, resveratrol also enhanced Sirt1 expression and improved GLUT4 translocation through insulin signaling pathway. Therefore, resveratrol is able to enhance the antioxidant status and insulin resistance in rat primary insulin-resistant adipocytes by exerting its antioxidant activity through Sirt1 pathway.

Key words: resveratrol, insulin resistance, antioxidation

CLC Number:

Q946.8

CHEN Si-fan1，XIAO Xin-cai2，SUN Yan-shuang1，ZHENG Lin1，ZHANG Zi-li1，FENG Xiang1,*. Effect of Resveratrol on Antioxidant Status and Insulin Sensitivity in Rat Primary Adipocytes[J]. FOOD SCIENCE, 2010, 31(13): 263-266.

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Effect of Resveratrol on Antioxidant Status and Insulin Sensitivity in Rat Primary Adipocytes

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