FOOD SCIENCE ›› 2011, Vol. 32 ›› Issue (5 ): 32-35.doi: 10.7506/spkx1002-6630-201105007

• Basic Research • Previous Articles     Next Articles

Inhibitory Potential of Trilobatin from Lithocarpus polystachyus Rehd against Key Enzymes Linked to Type Ⅱ Diabetes and Its Antioxidant Activity

ZHANG Yi1，NING Zheng-xiang1,*，DONG Huang-qiang2   

  1. 1. College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510641, China；
    2. Department of Food Science, Foshan University, Foshan 528231, China
  • Received:2010-07-06 Revised:2011-01-17 Online:2011-03-15 Published:2011-03-03
  • Contact: ZHANG Yi E-mail:zhangyi85518@yahoo.com.cn

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Abstract: The inhibitory effects of trilobatin separated from Lithocarpus polystachyus Rehd on the activities of α-glucosidase and α-amylase were determined and compared with those of the anti-diabetic drug acarbose as a positive control and the type of the enzymatic inhibition on α-amylase was investigated. Also, rutin was used as a positive control to measure the ability of the trilobatin from Lithocarpus polystachyus Rehd to scavenge DPPH free radicals. The results showed that α-glucosidase activity was inhibited remarkably by the trilobatin, and the inhibition was noncompetitive and did not exhibit a significant difference when compared to acarbose. Its inhibition rate against α-amylase, however, was lower than that of acarbose despite of having stronger DPPH free radical scavenging effect than rutin. From these experimental results, a conclusion could be drawn that the trilobatin from Lithocarpus polystachyus Rehd is a potential anti-diabetic compound.

Key words: trilobatin, Lithocarpus polystachyus Rehd, α-glucosidase, α-amylase, diabetes

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