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Antitumor Activity of Cultured Fruiting Bodies of Cordyceps cicadae

CHEN Anhui1, SHAO Ying1, LI Jiwu2, JIANG Zhaozhi2, CHEN Hongwei1   

  1. 1. Jiangsu Key Construction Laboratory of Food Resource Development and Quality Safe, Xuzhou Institute of Technology,
    Xuzhou 221008, China; 2. Bozhou Qiancao Pharmaceutical Co. Ltd., Bozhou 236800, China
  • Online:2015-05-15 Published:2015-05-11


The antitumor activity of the cultured fruiting bodies of Cordyceps cicadae on Chinese hamster ovary (CHO) cells
was investigated by measuring cell viability using a resazurin reduction assay in comparison with that of wild Cordyceps
cicadae. The experimental results showed that both samples had antitumor activity and contained mid-polar compounds.
Two bioactive compounds, namely components 1 and 2, were separated from the cultured fruiting bodies of Cordyceps
cicadae. Component 1 was identified as cordycepin. Component 2 (50 μg/mL) was identified as a purified compound that
could inhibit the viability of CHO cells by up to (94.55±2.33)%.

Key words: cultivated Cordyceps cicadae, antitumor activity, Chinese hamster ovary (CHO) cells, cordycepin

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