Antitumor Activity of Cultured Fruiting Bodies of Cordyceps cicadae

doi:10.7506/spkx1002-6630-201509036

Abstract

Abstract:

The antitumor activity of the cultured fruiting bodies of Cordyceps cicadae on Chinese hamster ovary (CHO) cells
was investigated by measuring cell viability using a resazurin reduction assay in comparison with that of wild Cordyceps
cicadae. The experimental results showed that both samples had antitumor activity and contained mid-polar compounds.
Two bioactive compounds, namely components 1 and 2, were separated from the cultured fruiting bodies of Cordyceps
cicadae. Component 1 was identified as cordycepin. Component 2 (50 μg/mL) was identified as a purified compound that
could inhibit the viability of CHO cells by up to (94.55±2.33)%.

Key words: cultivated Cordyceps cicadae, antitumor activity, Chinese hamster ovary (CHO) cells, cordycepin

CLC Number:

Q939

CHEN Anhui1, SHAO Ying1, LI Jiwu2, JIANG Zhaozhi2, CHEN Hongwei1. Antitumor Activity of Cultured Fruiting Bodies of Cordyceps cicadae[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201509036.

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Antitumor Activity of Cultured Fruiting Bodies of Cordyceps cicadae

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