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Quantitative Evaluation of the Regulatory Effect of Cordyceps militaris on Human Body with the Intercellular Directed Weighted Communication Networks

MA Lina1,2,*, PANG Guangchang3,*, SUN Yong4 , CUI Zhenfu5   

  1. 1. School of Science, Tianjin University of Commerce, Tianjin 300134, China; 2. China Institute for Actuarial Science, Central University of Finance and Economics, Beijing 100081, China; 3. College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China; 4. Beijing Academy of Food Sciences, Beijing 100050, China; 5. Beijing Oriental Institute of Measurement and Testing, Beijing 100086, China
  • Online:2016-01-15 Published:2016-01-15

Abstract:

Based on the directed weighted graph, three intercellular wireless communication networks are constructed,
which are generated in young and healthy volunteers consuming Cordyceps militaris at low, medium and high doses. The
quantitative analyses on three intercellular networks are conducted by means of statistics. It is proved that these parameters
can quantitatively describe the conditions, properties, structures and functions of networks from different perspectives. These
wireless communication networks have a hierarchical structure, and demonstrate a certain robustness. Meanwhile, different
doses of Cordyceps militaris can change the importance and role of the cells during the wireless communications. The
consumption of Cordyceps militaris mainly plays a role in down-regulating the intercellular wireless communication network
in vivo. Therefore, Cordyceps militaris has good health protection and anti-inflammatory effect on metabolic syndrome (MS) and
cardiovascular or cerebrovascular diseases caused by allergic reaction and overnutrition. The middle dose exerts the greatest effect
from an average viewpoint. When further increasing the dose, the functional strength is contrarily lowered down. This shows that
Cordyceps militaris at various doses has nonlinear and dual-direction regulatory functions on organisms.

Key words: directed weighted graph, intercellular wireless communication networks, Cordyceps militaris, cytokines, degree, weight

CLC Number: