Abstract: Objective: To observe the effect of resveratrol on lipid metabolism and machanism in experimental hyperlipidemia rats. Methods: To feed high fat diet to set up the model of hyperlipidemia rat. The contents of TC, TG, LDL-C, HDL-C , apoA Ⅰ, apoB, AST and ALT level in serum were assaged respectively in hyperlipidemia rat which had been fed resveratrol 30mg/kg bw•d and 70mg/kg bw•d ig for 4 weeks respecfively. In addition, liver lipid, activities of LPL and HL and fecal bile acid were assaged. Results: The TC, TG LDL-c apoB, AST and ALT in serum decreased significantly in the hyperlipidemia rats fed with the resveratrol in comparison with high lipid control group. Resveratrol significantly increased the activity of liver LPL and HL and the excretion of fecal bile acid in hyperlipidemia rats. Moreover, Resveratrol could decrease AI and increase ratioes of HDL-c/TC and apoAI/apoB. Conclusions: Resveratrol inhibited arteriosclerosis by regulation of lipid metabolism in hyper- lipidemiar ats.

Key words: resveratrol, hyperlipidemia, rats