Abstract: Objective To study of Panax quiquefolium tablet on the anti-fatigue effect in mice. Method: Mice were randomly assigned to control group, low dose, middle dose and high dose experimental groups according to their body weights. Panax quiquefolium tablet were administered in experimental groups at doses of. 67, 133, 200mg/kg. The control mice were given water. After 30 days., the swimming test were carried out and the death time was observed and recorded, after the mice swimming for a period the blood were taken for determining Blood Urea Nitrogen (BUN) and Serum Lactic-acid. The liver were taken for determining the glycogen. Results: 67, 133, 200mg/kg dose could significantly prolonged swimming time, reduce BUN level , increased the liver glycogen storage and accelerate lactic-acid clearance after swimming. Conclusion: Panax quiquefolium tablet could alleviate physical fatigue in mice.

Key words: Panax quiquefolium tablet, anti-fatigue