Abstract: Objective: To study the hypoglycemic effect of Platycodon grandiflorum extract on diabetic ICR mice. Methods: Diabetic models were induced by the i.v. (intravenous) injection of streptozotocin (STZ) in ICR mice, and were divided into different groups, which were given 8, 4g/kg PGE, glibenclamide or water respectively. The effects of PGE on 28d blood glucose level of the STZ-diabetic mice were studied. Food, water intake, body weight, blood glucose, TC, TG, LDL-C, HDL-C and insulin levels were respectively tested. Result: After 28d drug administration, symptoms of diabetic mice fed PGE are alleviated obviously. Water and food intake of diabetic mice are decreased by oral administrations of PGE, and their body weight is increased. High and low doses of PVE suppress the level of blood glucose by 11.42% and 6.86% resptectively, and both doses of PGE also suppresse the levels of TC, TG and LDL-C, but increase the level of HDL-C remarkably. Insulin levels are also improved by PGE. PGE has the potential hypoglycemic effect and alleviate the diabetic symptoms on diabetic mice.

Key words: Platycodon grandiflorum, diabetes mellitus, ICR mice, blood glucose