Role of Bioactive Components of Allium chinense in Increasing Efficacy and Decreasing Toxicity of Fluorouracil

Abstract

Abstract: The present study was to investigate the inhibition of the bioactive components of Allium chinense to cervical cancer Hela cells and human gastric cancer cell line BGC-823 in vitro, its effect on the sensitivity of Hela and BGC-823 cells to 5-FU, and its protection for the immunological function of mice against the toxicity of 5-FU. The inhibition rate of cell proliferation was assayed by MTT method and the effect of the bioactive components of Allium chinense combined with 5-FU on mice was tested by the phagocytosing functions of macrophagocytes in abdominal cavity and activity of lymphocyte. The results showed that the bioactive components of Allium chinense combined with 5-FU markedly inhibited the proliferation of Hela cells and BGC-823 cell and decresed toxicity and side-effect of 5-FU to macrophagocyte and lymphocyte. It is suggested that the bioactive components of Allium chinense combined with 5-FU have an obvious effect on inhibiting tumor with decreased toxicity and side-effect.

Key words: bioactive components of Allium chinense, fluorouracil, cancer cells, increasing efficacy, immunity

SUN Yun-Jun, LIU Zhuo-Ling, DING Xue-Zhi, QIAN Rong-Hua, MO Xiang-Tao, XIA Li-Qiu. Role of Bioactive Components of Allium chinense in Increasing Efficacy and Decreasing Toxicity of Fluorouracil[J]. FOOD SCIENCE, 2007, 28(12): 462-465.

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Role of Bioactive Components of Allium chinense in Increasing Efficacy and Decreasing Toxicity of Fluorouracil

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