Optimization of Ultrasonic-Assisted Hydroxypropyl-β-Cyclodextrin Embedding of α-Linolenic Acid from Zanthoxylum bungeanum Maxim Seeds

Abstract

Abstract: In order to optimize the ultrasonic-assisted hydroxypropyl-β-cyclodextrin (HP-β-CD) embedding of α-linolenic acid from Zanthoxylum bungeanum Maxim seeds, the effects of ultrasonic power, ultrasonic treatment time and mass ratio between absolute ethanol plus mixed FFAs and HP-β-CD on embedding efficiency were explored. The results indicated that the optimal embedding conditions were ultrasonic power of 300 W, ultrasonic treatment time of 20 min and (ethanol + FFAs)-to-HP-β-CD mass ratio of 1:8. Under these conditions, the embedding rate of α-linolenic acid reached up to 90.25%, which allowed the safe and non-toxic separation of α-linolenic acid.

Key words: hydroxypropyl-β-cyclodextrin, Zanthoxylum bungeanum Maxim seeds, α-linolenic acid, ultrasonic, high performance liquid chromatography

CLC Number:

S565.9

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