Effects of Imperata cylindrica Polysaccharides on Glucose and Lipid Metabolism in Diabetic Mice

Abstract

Abstract: Objective: To study the effects of Imperata cylindrica polysaccharides on blood glucose and lipid in diabetic mice. Method: Diabetes was induced by intraperitoneal injection of streptozotocin in mice. The changes of body mass, glucose tolerance, blood lipid parameters, GSP and liver glycogen of mice were examined. Results: Blood glucose and blood lipid levels of diabetic mice were significantly ameliorated by administration of Imperata cylindrica polysaccharides. Compared with diabetic control mice, Imperata cylindrica polysaccharides significantly decreased GSP, TG, TC, and LDL-C levels of mice, and remarkably increased liver glycogen and HDL-C levels. Comparable results were obtained using metformin hydrochloride. Conclusion: Imperata cylindrica polysaccharides are effective in ameliorating the metabolism of blood glucose and lipids in diabetic mice.

Key words: Imperata cylindrica polysaccharides, diabetes, hypoglycemic effect, blood lipid

CLC Number:

S896.6

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Effects of Imperata cylindrica Polysaccharides on Glucose and Lipid Metabolism in Diabetic Mice

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