Rapid Screening of 73 Toxic and Harmful Substances in Foods by Ultra Performance Liquid Chromatography-Mass Spectrometry with QuEChERS

doi:10.7506/spkx1002-6630-201316043

Abstract

Abstract:

An ultra performance liquid chromatography-mass spectrometry (UPLC-MS-MS) with QuEChERS method
has been developed for the determination of 73 toxic and harmful substances in foods. Samples were extracted by DisQuE
extraction, cleaned up with DisQuE clean-up tube, and chromatographic separation was performed on a BEH C18 column
with gradient elution and the analytes were identified by multiple reaction monitoring (MRM) and quantified by external standard
method. The results showed that the limits of quantification (LOQs) for 73 toxic and harmful substances were 0.1－50 μg/kg.
The recoveries at low, medium and high spiked levels and the relative standard deviations (RSD) were 62.05%－112.75%
and 3.11%－10.04%, respectively. This method proved to be rapid, simple, and suitable for the rapid screening of toxic and
harmful substances in foods.

Key words: ultra performance liquid chromatography-mass spectrometry (QuEChERS), ultra performance liquid chromatography-mass spectrometry (UPLC-MS-MS), alkaloids, mycotoxins, pesticides, screening

FENG Nan，LU Yong，JIANG Jie，CHEN Jun-hui，ZHAO Jun-ping，XIE Wen-dong. Rapid Screening of 73 Toxic and Harmful Substances in Foods by Ultra Performance Liquid Chromatography-Mass Spectrometry with QuEChERS[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201316043.

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Rapid Screening of 73 Toxic and Harmful Substances in Foods by Ultra Performance Liquid Chromatography-Mass Spectrometry with QuEChERS

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