FOOD SCIENCE
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ZHANG Ziwei, LI Ying, CAO Peng, LI Xiaoyan*
Online:
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Abstract: Dioscin has been reported for its good anticancer activity. Dioscin can induce cell apoptosis by regulating reactive oxygen species, B-cell lymphoma 2 family proteins and cell cycle, modulating signaling pathways and enzymes involved in them and stimulating cell differentiation through the mitochondrial pathway and the death receptor pathway, and thus exerts an anticancer effect. This paper reviews the anticancer mechanism of dioscin with respect to reversal of multi-drug resistance, antiinflammatory effect, expression of matrix metalloproteinases, effect on epidermal growth factor and inhibition of angiogenesis. Finally, prospects for the future development and application of dioscin as an anticancer agent are discussed.
Key words: dioscin, anticancer mechanism, natural products
CLC Number:
TS209
ZHANG Ziwei, LI Ying, CAO Peng, LI Xiaoyan. Progress in Research on Anticancer Mechanism of Dioscin[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201701049.
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URL: https://www.spkx.net.cn/EN/10.7506/spkx1002-6630-201701049
https://www.spkx.net.cn/EN/Y2017/V38/I1/297