FOOD SCIENCE ›› 2021, Vol. 42 ›› Issue (23): 355-363.doi: 10.7506/spkx1002-6630-20200818-244

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Progress in Understanding the Structure-Activity Relationship and Hypoglycemic Mechanism of Polysaccharides

YANG Yujie, LIU Jingyi, TAN Yan, WANG Shuhui, CHEN Hanmin, ZHOU Aimei   

  1. (1. Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou 510642, China; 2. Guangdong Zhancui Food Co., Ltd., Chaozhou 515634, China)
  • Online:2021-12-15 Published:2021-12-29

Abstract: Diabetes is a metabolic disease characterized by hyperglycemia. The incidence of diabetes has been increasing year by year. Diabetes treatments mainly with Western medicines can cause side effects, which will stimulate people to turn their attention to natural bioactive substances. As a group of safe, low-toxic natural substances, polysaccharides have many biological activities such as hypoglycemic activity and thus have great development potential. In this paper, the relationship between the hypoglycemic activity and structure of polysaccharides is reviewed with respect to molecular mass, monosaccharide composition, glycosidic bonds, advanced structures and groups, and the mechanism of the hypoglycemic action of polysaccharides is summarized. Furthermore, problems existing in this field of research and future research directions are discussed.

Key words: polysaccharides; hypoglycemic activity; structure-activity relationship; hypoglycemic mechanism

CLC Number: