食品科学 ›› 2013, Vol. 34 ›› Issue (7): 293-295.doi: 10.7506/spkx1002-6630-201307062

• 营养卫生 • 上一篇    下一篇

宝乐果(Borojo)水果浓缩粉对D-半乳糖致衰老小鼠的抗氧化作用

战 静1,2,焦 红1,*,王家骥3,陈骁熠3,孟 平1   

  1. 1.广东出入境检验检疫局,广东 广州 510623;2.青岛市食品药品监督管理局,山东 青岛 266000; 3.广州医学院公共卫生学院,广东 广州 510083
  • 收稿日期:2012-02-24 修回日期:2013-02-27 出版日期:2013-04-15 发布日期:2013-03-20
  • 通讯作者: 焦红 E-mail:jhciq1228@163.com
  • 基金资助:
    广东省科技计划项目(2011B010500014;2012A020602046);广州市科技计划项目(11A61030347)

Anti-aging Effects of Concentrated Powder of Borojo Fruit on Aging Mice Induced by D-Galactose

ZHAN Jing1,2, JIAO Hong1,*, WANG Jia-ji3, CHEN Xiao-yi3, MENG Ping1   

  1. 1. Guangdong Entry-Exit Inspection and Quarantine Bureau, Guangzhou 510623, China;2. Qingdao Food and Drug Administration, Qingdao 266000, China;3. College of Public Health, Guangzhou Medical College, Guangzhou 510083, China
  • Received:2012-02-24 Revised:2013-02-27 Online:2013-04-15 Published:2013-03-20
  • Contact: JIAO Hong E-mail:jhciq1228@163.com

摘要: 目的:研究宝乐果(Borojo)水果浓缩粉对D-半乳糖致衰老小鼠的抗氧化作用。方法:昆明种雄性小鼠腹腔注射50mg/kg D-半乳糖建立衰老模型,用Borojo水果浓缩粉连续给小鼠灌胃30d,测定各组小鼠血清及肝脏中的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活力及丙二醛(MDA)的含量。结果:Borojo水果浓缩粉的中剂量组(4.0g/(kg·d))和高剂量组(6.0g/(kg·d))小鼠血清和肝脏的SOD活力显著提高(P<0.05)、血清MDA含量显著降低(P<0.05);高剂量组小鼠血清和肝脏中GSH-Px活力显著提高(P<0.05),肝脏MDA含量显著降低(P<0.05)。结论:Borojo水果浓缩粉具有良好的体内抗氧化作用。

关键词: 宝乐果, D-半乳糖, 小鼠衰老模型, 抗氧化

Abstract: Objective: To study the anti-aging effect of concentrated powder of Borojo fruit on aging mice induced by D-galactose. Methods: Kunming male mice were treated with 50 mg/kg D-galactose to create aging model by intraperitoneal injection. Mice were fed Borojo fruit concentrated powder by gavage continuously for 30 days. The activities of SOD and GSH-Px and the content of MDA in mouse serum and liver were determined. Results: Borojo fruit concentrated powder at middle dose (4.0 g/(kg·d) and high dose (6.0 g/(kg·d) improved SOD activity and significantly decreased MDA content in the serum and liver of mice, and at high dose significantly improved GSH-Px activity in the serum and liver. Conclusion: Borojo fruit concentrated powder has strong in vivo anti-aging effects. It can be applied for the development of health functional food.

Key words: Borojo, D-galactose, aging model mice, anti-aging

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