in vitro and in vivo Inhibitory Effect of Methanol Extract from Terminalia chebula Retz Fruits on α -Glucosidase

doi:10.7506/spkx1002-6300-201007063

FOOD SCIENCE ›› 2010, Vol. 31 ›› Issue (7): 284-287.doi: 10.7506/spkx1002-6300-201007063

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in vitro and in vivo Inhibitory Effect of Methanol Extract from Terminalia chebula Retz Fruits on α -Glucosidase

JING Zan1，ZENG Wei-cai1，LUO Jing-wen2，YE Hua-xia1，HUANG Yi-na2，GAO Hong1,*

1.College of Light Industry, Textile and Food Engineering, Sichuan University, Chengdu 610065, China；
2. West China of Public Health , Sichuan University, Chengdu 610041, China

Received:2009-07-24 Online:2010-04-01 Published:2010-12-29
Contact: GAO Hong E-mail:gao523@hotmail.com

Abstract

Abstract:

In order to evaluate the inhibitory effect of Terminalia chebula Retz fruit extract (TCFE) on α-glucosidase, Caco- 2 cells were used to assay the inhibitory activity of TCFE in vitro and in small intestinal model. Results indicated that TCFE exhibited a strong inhibitory effect on maltase, while no obvious inhibitory activity on sucrase in vitro was observed. In addition, TCFE also obviously reduced 30 min postadministration blood glucose level of SD maltose-loaded male rats. On the other hand, this extract had no effect on the postprandial blood glucose level in normal SD rats administrated sucrose. These results suggest that TCFE has a preventive effect against Type II diabetes.

Key words: Terminalia chebula Retz, &alpha, -glucosidase inhibitor, blood glucose level, diabetes

CLC Number:

TS218

JING Zan1，ZENG Wei-cai1，LUO Jing-wen2，YE Hua-xia1，HUANG Yi-na2，GAO Hong1,*. in vitro and in vivo Inhibitory Effect of Methanol Extract from Terminalia chebula Retz Fruits on α -Glucosidase[J]. FOOD SCIENCE, 2010, 31(7): 284-287.

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in vitro and in vivo Inhibitory Effect of Methanol Extract from Terminalia chebula Retz Fruits on α -Glucosidase

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