关键词: 双歧杆菌, IgG, 悬浮造粒, 微胶囊, 肠溶性

Abstract:

Bacillus bifidus and immunoglobulin are materials with fundamental biological activities in immune colostrum. However, the activities of Bacillus bifidus and immunoglobulin are greatly damaged by proteases and bile in gastrointestinal tract, which brings a challenge in the utilization of Bacillus bifidus and immunoglobulin in food processing. The powder of fermented immune colostrum with Bacillus bifidus was obtained by lyophilization. A kind of intestinal soluble microcapsules was prepared using lyophilized powder as the core material, Opadry as the wall material and protectant as wetter through air suspension microencapsulation technology. The preparation process was explored by orthogonal array design experiments. The optimal conditions for microcapsules were 200 m3/h for air-input capacity, 45 ℃ for air-input temperature, 36 ℃ for air-release temperature, 37 ℃ for material temperature and 6 r/min for gunite speed.

Key words: Bacillus bifidus, immunoglobulin, air suspension microencapsulation technology, microcapsule, intestinal solubility