酪蛋白磷酸肽、高钙膳食及二者复合物结合高钙膳食对高尿酸血症大鼠的影响

doi:10.7506/spkx1002-6630-201021075

食品科学 ›› 2010, Vol. 31 ›› Issue (21): 332-334.doi: 10.7506/spkx1002-6630-201021075

酪蛋白磷酸肽、高钙膳食及二者复合物结合高钙膳食对高尿酸血症大鼠的影响

张锐¹，姚芳芳¹，何伟^2,*

1.郑州大学公共卫生学院
2.河南省医药科学研究院

收稿日期:2010-03-19 出版日期:2010-11-15 发布日期:2010-12-29
通讯作者: 何伟 E-mail:weibho@163.com

Effects of Casein Phosphopeptides, High-calcium Diet and Their Combination on Hyperuricemic Rats

ZHANG Rui1，YAO Fang-fang1，HE Wei2,*

1. College of Public Health, Zhengzhou University, Zhengzhou 450001, China；
2. Medical Research Institute of Henan Province, Zhengzhou 450052, China

Received:2010-03-19 Online:2010-11-15 Published:2010-12-29
Contact: HE Wei E-mail:weibho@163.com

摘要/Abstract

摘要：

目的：研究酪蛋白磷酸肽(CPPs)、钙粉及二者复合物对高尿酸血症大鼠血清尿酸(UA)、总胆固醇(TC)、黄嘌呤氧化酶(XOD)、腺苷脱氨酶(ADA)及肝脏XOD 和ADA 的影响。方法：用腺嘌呤(100mg/(kg bw·d))+ 乙胺丁醇(250mg/(kg bw·d))给大鼠灌胃3 周，造成高尿酸血症模型，再在饲料中加入酪蛋白磷酸肽、钙粉以及二者复合物对其进行干预28d。结果：干预前造模大鼠的血尿酸水平高于空白组；和模型组相比，各干预组大鼠血清UA 和TC 水平均降低，同时各组肝脏中XOD、血清和肝脏中ADA 活性均低于模型组，其中复合组的效果最为明显(P ＜ 0.05)。结论：酪蛋白磷酸肽结合钙粉可相对更好地促进尿酸降低。

关键词: 高尿酸血症, 酪蛋白磷酸肽, 钙, 尿酸, 总胆固醇

Abstract:

Objective: To study the effects of casein phosphopeptides (CPPs), high-calcium diet and their combination on uric acid (UA), total cholesterol (TC), xanthine oxidase (XOD) and adenosine deaminase (ADA) in the serum and XOD and ADA in the liver of hyperuricemic rats. Methods: Hyperuricemic model rats were induced by intragastric administration with adenine (100 mg/(kg bw·d)) and ethambutol (250 mg/(kg bw·d)) for 3 weeks. The model rats were then treated with foods containing CPPs, high-calcium diet and their combination for 28 days. After intervention for 28 days, UA, TC, XOD and ADA in serum and XOD and ADA in liver were determined. Results: Serum uric acid level of rats induced by intragastric administration was significantly higher than that in the control group before intervention. Compared with the model rats, each intervention group exhibited an obvious decrease in UA and TC levels. The XOD activities in all the intervention groups were all lower than those in the liver of the model group, and the ADA activities in all the intervention groups were lower than those in both the serum and liver of the model groups, especially in high-calcium diet and their combination intervention groups (P < 0.05). Conclusion: CPPs and high-calcium diet exhibit a high potential to decrease uric acid level.

Key words: hyperuricemic, casein phosphopeptides, calcium, uric acid, total cholesterol

中图分类号:

R151.3

张锐1，姚芳芳1，何伟2,*. 酪蛋白磷酸肽、高钙膳食及二者复合物结合高钙膳食对高尿酸血症大鼠的影响[J]. 食品科学, 2010, 31(21): 332-334.

ZHANG Rui1，YAO Fang-fang1，HE Wei2,*. Effects of Casein Phosphopeptides, High-calcium Diet and Their Combination on Hyperuricemic Rats[J]. FOOD SCIENCE, 2010, 31(21): 332-334.

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酪蛋白磷酸肽、高钙膳食及二者复合物结合高钙膳食对高尿酸血症大鼠的影响

Effects of Casein Phosphopeptides, High-calcium Diet and Their Combination on Hyperuricemic Rats

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