食品科学
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杨 叶,李 磊*
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基金资助:
国家自然科学基金项目(81072338)
YANG Ye,LI Lei*
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摘要:
咖啡酸及其衍生物(CADs)广泛存在于日常的食品/膳食中,在抑制肿瘤细胞生长、分化、增殖和转移过程中发挥重要作用。本文对CADs从氧化应激、相关信号通路及转录因子改变、上皮-间质转化、肿瘤干细胞特性和表观遗传学调控等方面阐述其抗肿瘤作用分子机制,为研究食品中生物活性因子的健康促进作用和膳食干预提供一定的参考。
关键词: 咖啡酸衍生物, 抗肿瘤, 机制
Abstract:
Caffeic acid and its derivatives (CADs) are widely spread in the daily foods/meals, and play an important role in the suppression of tumor cell growth, differentiation, proliferation and transfer process. This article reviews the molecular mechanisms such as the effects of CADs on tumor suppression through oxidative stress, signaling pathways and transcription factors, epithelial-mesenchymal transition, cancer stem cell-like properties, and epigenetic regulation in order to provide a reference for health-promoting function of active components in food and dietary intervention.
Key words: caffeic acid derivatives, anti-tumor, molecular mechanisms
中图分类号:
TS201.24
杨 叶,李 磊*. 咖啡酸及其衍生物抗肿瘤作用分子机制研究进展[J]. 食品科学, doi: 10.7506/spkx1002-6630-201319070.
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链接本文: https://www.spkx.net.cn/CN/10.7506/spkx1002-6630-201319070
https://www.spkx.net.cn/CN/Y2013/V34/I19/341