季铵盐类消毒剂及大肠杆菌对其耐药性研究进展

doi:10.7506/spkx1002-6630-201417063

食品科学

季铵盐类消毒剂及大肠杆菌对其耐药性研究进展

邹立扣，吴国艳，程琳，何雪梅，郭丽娟，龙梅

1.四川农业大学都江堰校区微生物学实验室，四川都江堰 611830；2.四川农业大学资源环境学院，四川成都 611130

出版日期:2014-09-15 发布日期:2014-09-12

Progress in Research on the Resistance of Escherichia coli to Quaternary Ammonium Compounds (QACs)

ZOU Li-kou, WU Guo-yan, CHENG Lin, HE Xue-mei, GUO Li-juan, LONG Mei

1. Laboratory of Microbiology, Dujiangyan Campus of Sichuan Agricultural University, Dujiangyan 611830, China;
2. College of Resources and Environment, Sichuan Agricultural University, Chengdu 611130, China

Online:2014-09-15 Published:2014-09-12

摘要/Abstract

摘要：

研究表明，食源性细菌消毒剂耐药严重，大肠杆菌是食品污染状况及耐药性监测的指示菌，对季铵盐类消毒剂表现出比革兰氏阳性菌更强的抗性，且大肠杆菌对消毒剂与抗生素耐药性可共传播。鉴于此，本文综述了季铵盐类消毒剂的结构与种类、作用机制、大肠杆菌消毒剂耐药产生、耐药基因、基因型与表型的关系以及与抗生素耐药共传播机制等的研究进展。食源性大肠杆菌对季铵盐类消毒剂抗性的耐药机制研究很少，研究大肠杆菌对季铵盐类消毒剂耐药性，可为消毒剂的规范使用以及食源性大肠杆菌的防控提供科学依据及理论基础。

关键词: 大肠杆菌, 季铵盐类, 消毒剂, 耐药

Abstract:

Current studies have demonstrated the serious disinfectant resistance in food-borne bacteria. Escherichia coli as
an indicator bacterium for food contamination and drug resistance reveals much higher resistance to quaternary ammonium
compounds (QACs) than do Gram-positive bacteria. In addition, the resistance to QACs and antibiotics can be disseminated
and co-transmitted, thus resulting in co-selected disinfectant and antibiotics-resistant bacteria. Therefore, the chemical
structure, species and mechanism of action of QACs, the genetic mechanism as well as genotype and phenotype underlying
QACs resistance of Escherichia coli, and the mechanism of co-transmission with antibiotic resistance are summarized
in this article. To date, little is known about the mechanism of disinfectant resistance in food-borne E. coli. Thus, further
research on the disinfectant resistance is needed. Understanding the mechanism of QACs resistance of E. coli can provide a
theoretical and scientific basis for regulating the use of disinfectants and preventing food-borne E. coli infections.

Key words: Escherichia coli, quaternary ammonium compounds, disinfectant, antibiotic resistance

中图分类号:

Q93
TS207.4

邹立扣，吴国艳，程琳，何雪梅，郭丽娟，龙梅. 季铵盐类消毒剂及大肠杆菌对其耐药性研究进展[J]. 食品科学, doi: 10.7506/spkx1002-6630-201417063.

ZOU Li-kou, WU Guo-yan, CHENG Lin, HE Xue-mei, GUO Li-juan, LONG Mei. Progress in Research on the Resistance of Escherichia coli to Quaternary Ammonium Compounds (QACs)[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201417063.

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季铵盐类消毒剂及大肠杆菌对其耐药性研究进展

Progress in Research on the Resistance of Escherichia coli to Quaternary Ammonium Compounds (QACs)

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