柴达木盆地唐古特白刺籽油的安全性与降血脂作用

食品科学 ›› 2005, Vol. 26 ›› Issue (11): 217-219.

柴达木盆地唐古特白刺籽油的安全性与降血脂作用

索有瑞, 王洪伦, 陈桂琛

中国科学院西北高原生物研究所

出版日期:2005-11-15 发布日期:2011-10-01

Research on Security and Decreasing Blood Lipid Effect of Nitraria Seed Oil from Qaidam Basin

SUO You-Rui, WANG Hong-Lun, CHEN Gui-Chen

Northwest Plateau Institute of Biology, Chinese Academy of Sciences

Online:2005-11-15 Published:2011-10-01

摘要/Abstract

摘要： 对柴达木唐古特白刺种籽油的安全性和降血脂作用进行了研究。以超临界CO2萃取技术提取白刺种籽油,采用小白鼠进行急性毒性实验和安全性评价,以高脂饲料诱导建立大鼠高脂动物模型,灌胃种籽油4w,测定动物血清血脂水平。结果表明,小鼠每日给予白刺籽油40ml/kg,连续观察14d,无毒性表现,服用安全;种籽油5g/kg和10g/kg剂量对高脂饲料诱导的大鼠血清TC、TG及LDL具有显著的抑制作用,可显著升高高血脂大鼠HDL/TC和HDL/LDL的比值,表明高剂量白刺种籽油具有显著的降血脂作用。

关键词: 唐古特白刺, 种籽油, 安全性评价, 降血脂

Abstract: To study the security and decreasing blood lipid effect of seed oil of Nitraria tangutorum Bobr. from Qinghai Qaidam Basin, the seed oil extracted by supercritical CO2 fluid extraction (SFE-CO2) from Nitraria seeds was investigated for the acute toxicity and its security was evaluated. The blood lipid levels in the serum of each animal group with the hyperlipemia models of Wistart rat and Kunming strain mice induced by feed with high lipids were determined after oral administration for 4 weeks with the seed oil. It showed that the mice were secure by feeding the seed oil at the dose of 40ml/kg d after 14 days; but the seed oil of Nitraria tangutorum Bobr. fed at the dose of 5g/kg and 10g/kg not only showed significant inhibition effect on TC, TG and LDL levels in serum of hyperlipemia model of Wistar rat, but also increased the ratio of HDL/TC and HDL/LDL. That illustrated that the high dose of seed oil of Nitraria tangutorum Bobr. has the decreasing blood lipid effect.

Key words: Nitraria tangutorum Bobr., Nitraria seed oil, security evaluation, decreasing blood lipid effect

索有瑞, 王洪伦, 陈桂琛. 柴达木盆地唐古特白刺籽油的安全性与降血脂作用[J]. 食品科学, 2005, 26(11): 217-219.

SUO You-Rui, WANG Hong-Lun, CHEN Gui-Chen. Research on Security and Decreasing Blood Lipid Effect of Nitraria Seed Oil from Qaidam Basin[J]. FOOD SCIENCE, 2005, 26(11): 217-219.

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