食品科学 ›› 2007, Vol. 28 ›› Issue (2): 293-297.

• 营养卫生 • 上一篇    下一篇

乌贼墨制品对60Coγ辐射损伤小鼠造血功能的影响

 雷敏, 王静凤, 李兆杰, 逄龙, 董平, 薛长湖   

  1. 中国海洋大学食品科学与工程学院; 中国海洋大学食品科学与工程学院 山东青岛266003; 山东青岛266003;
  • 出版日期:2007-02-15 发布日期:2011-12-31

Effects of Sepia Product on Hemapoiecsis Promotion in 60Coγ Irradiated Mice

 LEI  Min, WANG  Jing-Feng, LI  Zhao-Jie, PANG  Long, DONG  Ping, XUE  Chang-Hu   

  1. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China
  • Online:2007-02-15 Published:2011-12-31

摘要: 目的:探讨乌贼墨制品对60Coγ辐射损伤小鼠造血功能的影响。方法:采用造血祖细胞体外培养方法、实验血液学技术等方法,检测模型小鼠脾指数及胸腺指数、骨髓有核细胞数(BMNC)、骨髓造血干细胞生成数(CFU-S)、粒-单系祖细胞集落生成数(CFU-GM)、外周血象和血清超氧化物岐化酶(SOD)活力。结果:乌贼墨制品能够有效拮抗60Coγ辐射损伤模型小鼠体内BMNC、CFU-S、CFU-GM、外周WBC及血清SOD活力的降低,并显著促进其恢复;但对外周血RBC、PLT、Hb均无显著影响。结论:乌贼墨制品能够显著促进辐射损伤小鼠骨髓粒系造血作用。

关键词: 乌贼墨制品, 60Co&gamma, 辐射损伤, 造血机能, SOD

Abstract: Objective: To investigate the activation effects of sepia product on hematopoietic function in 60Coγirradiated mice. Methods: Model mice of hematopoietic system impairment were induced by whole body 60Coγirradiaion with the lethal dose of 8.0 Gy and then given different dosage of sepia products respectively. Spleen and thymus indexes, numbers of bone marrow nucleated cells (BMNC), colony-forming units in spleen (CFU-S), colony-forming units of granulocyte and monocyte(CFU- GM), peripheral blood pictures and serum SOD activity in model mice were assayed respectively. Results: Sepia products could resist the decrease of BMNC(p<0.05, p<0.01), CFU-S(p<0.05, p<0.01), CFU-GM(p<0.01), and peripheral WBC (p <0.01) and promote the restoration of those indices mentioned above in model mice significantly (p<0.05, p<0.01), but have no significant effects on peripheral RBC, PLT and Hb respectively. Conclusion: Sepia production has significant promoting effects on hemapoiecsis.

Key words: sepia production; 60Co&gamma, irradiation impairment; hematopoitic function; SOD;