食品科学 ›› 2008, Vol. 29 ›› Issue (10): 694-697.
• 专题论述 • 上一篇 下一篇
杨滢滢, 王雪青, 庞广昌
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YANG Ying-Ying, WANG Xue-Qing, PANG Guang-Chang
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摘要: 原花青素是由(+)-儿茶酚和(-)-表儿茶酸组成的低聚或多聚酚类化合物,具有抗氧化、清除自由基、抗炎和抗癌的生理活性。本文综述了原花青素在抗氧化和清除自由基、抗炎、调节信号转导、促进肿瘤细胞凋亡、细胞周期阻滞和抑制血管生成等方面抗癌机制的最新研究进展。
关键词: 原花青素, 抗氧化, 抗癌, 信号转导, 细胞凋亡
Abstract: Proanthocyanidins are a class of phenolic oligomers or polymers that consisit of (+)-catechin and (-)-epicatechin. They have antioxidant,free radicals scavenging,antiinflammatory and anticancer activities. This paper summarized the latest research developments of anti-carcinogenic mechanism of proanthocyanidins about antioxidation,scavenging free radical,anti-inflammatory activity,regulatory signal transduction,pro-apoptotic effect,cell cycle arrest and inhibition of angiogenesis.
Key words: proanthocyanidins, antioxidant, anticancer, signal transduction, apoptosis
杨滢滢, 王雪青, 庞广昌. 原花青素抗肿瘤作用机制研究进展[J]. 食品科学, 2008, 29(10): 694-697.
YANG Ying-Ying, WANG Xue-Qing, PANG Guang-Chang. Research Developments of Anti-carcinogenic Mechanism of Proanthocyanidins[J]. FOOD SCIENCE, 2008, 29(10): 694-697.
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