食品科学 ›› 2008, Vol. 29 ›› Issue (10): 694-697.

• 专题论述 • 上一篇    下一篇

原花青素抗肿瘤作用机制研究进展

 杨滢滢, 王雪青, 庞广昌   

  1. 天津市食品与生物技术重点实验室,天津商业大学生物技术与食品科学学院;
  • 出版日期:2008-10-15 发布日期:2011-12-08

Research Developments of Anti-carcinogenic Mechanism of Proanthocyanidins

 YANG  Ying-Ying, WANG  Xue-Qing, PANG  Guang-Chang   

  1. Tianjin Key Laboratory of Food and Biotechnology,College of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin 300134,China
  • Online:2008-10-15 Published:2011-12-08

摘要: 原花青素是由(+)-儿茶酚和(-)-表儿茶酸组成的低聚或多聚酚类化合物,具有抗氧化、清除自由基、抗炎和抗癌的生理活性。本文综述了原花青素在抗氧化和清除自由基、抗炎、调节信号转导、促进肿瘤细胞凋亡、细胞周期阻滞和抑制血管生成等方面抗癌机制的最新研究进展。

关键词: 原花青素, 抗氧化, 抗癌, 信号转导, 细胞凋亡

Abstract: Proanthocyanidins are a class of phenolic oligomers or polymers that consisit of (+)-catechin and (-)-epicatechin. They have antioxidant,free radicals scavenging,antiinflammatory and anticancer activities. This paper summarized the latest research developments of anti-carcinogenic mechanism of proanthocyanidins about antioxidation,scavenging free radical,anti-inflammatory activity,regulatory signal transduction,pro-apoptotic effect,cell cycle arrest and inhibition of angiogenesis.

Key words: proanthocyanidins, antioxidant, anticancer, signal transduction, apoptosis