甘薯抗性淀粉对高脂血症大鼠降脂利肝作用研究

食品科学 ›› 2012, Vol. 33 ›› Issue (1): 244-247.

甘薯抗性淀粉对高脂血症大鼠降脂利肝作用研究

于淼，邬应龙*

四川农业大学食品学院

收稿日期:2011-03-18 修回日期:2012-01-04 出版日期:2012-01-15 发布日期:2012-01-12
通讯作者: 邬应龙 E-mail:wuyinglong99@163.com
基金资助:
四川省科技支撑计划项目

Hypolipidemic and Liver-Benefiting Effect of Sweet Potato Resistant Starch in Hyperlipidemic Rats

Received:2011-03-18 Revised:2012-01-04 Online:2012-01-15 Published:2012-01-12

摘要/Abstract

摘要： 目的：考察甘薯抗性淀粉(SPRS)在大鼠形成高脂血症过程中的降血脂及促进肝损伤修复的作用。方法：取健康成年SD大鼠，雌雄各半，40只随机分为4组：正常对照组(NG)、高脂模型组(HL)、甘薯抗性淀粉低剂量组(SPRSL)、甘薯抗性淀粉高剂量组(SPRSH)。正常对照组饲喂基础饲料，高脂模型组饲喂高脂饲料，甘薯抗性淀粉组在高脂饲料的基础上分别给予甘薯抗性淀粉10、20g/(kg·d)，45d后测定大鼠血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的含量及观察肝脏组织细胞形态变化。结果表明：甘薯抗性淀粉能显著降低TC、TG、LDL-C水平，提高HDL-C水平；甘薯抗性淀粉组肝细胞变性和坏死现象明显轻于高脂模型组。结论：甘薯抗性淀粉对高脂饲料致高脂血症大鼠的血脂水平有较好的调节作用，并明显改善大鼠的肝功能。

关键词: 甘薯抗性淀粉, 高脂血症, 降血脂, 肝功能

Abstract: Objective: To examine whether sweet potato resistant starch (SPRS) lowers blood lipid levels and benefits the liver of hyperlipidemic rats. Methods: Forty SD rats (half male and half female) were randomly divided into 4 groups including normal control group, hyperlipidemia model group, SPRS low-dose group and SPRS high-dose group. Rats fed a normal diet were served as the normal control group and rats fed a high-fat diet as the hyperlipidemia model group. The rats in SPRS groups were administered with SPRS by gavage at the daily doses of respectively 10 g/(kg·d) and 20 g/(kg·d) and also fed a high-fat diet. After 45 days of administration, serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and morphological changes in the liver of all the rats were examined. Results: SPRS could significantly reduce the contents of TC, TG and LDL-C, and increase the content of HDL-C in rat serum. Meanwhile, the liver degeneration and damage of the SPRS groups were markedly attenuated compared with the hyperlipidemia model group. Conclusion: SPRS has an excellent regulatory effect on blood lipid level and enhances the recovery of liver damage in rats with hyperlipidemia.

Key words: sweet-potato resistant starch, hyperlipemia, blood lipid lowering effect, hepatic function

中图分类号:

TS235.2

于淼，邬应龙* . 甘薯抗性淀粉对高脂血症大鼠降脂利肝作用研究[J]. 食品科学, 2012, 33(1): 244-247.

参考文献

参考文献：
[1]Basciano H, FedericoL. fructose,insulin resistance and metabolic dyslipidemia[J]. Nutr Metab,2005,2(1): 1–14.
[2]María A. The reduction of dietary sucrose improves dyslipidemia, adiposity, and insulin secretion in an insulin
resistant rat model[J]. Nutrition ,2007,23:489–497.
[3]郑茂强,金征宇.木薯交联酯化麦芽糊精的抗酶解性及生理功能[J].食品与发酵工业,2008,34(3):132-136.
[4]杨月欣.抗性淀粉的功能作用[J].中国食品与营养,2000,6:45—46.
[5]尚晓娅.抗性淀粉食品安全性毒理学研究[J].毒理学杂志,2006,20(5):310-313.
[6]付蕾,田纪春.抗性淀粉制备、生理功能和应用研究进展[J].中国粮油学报,2008,23(2):206-209.
[7]Englyst, H. N.; Kingman, S. M.; Cummings, H. J. Eur. J. Clin. Nutr.1992, 46, 33–50.
[8]Kim WK ,Chung MK,Kang NE, et a1．Effect of resistant starch from corn or rice on glucose control,colonic events and blood lipid concentrations in streptozotocin induced diabetic rats[J].Nutr Biechem,2003,14(3):166-172.
[9]Rancon F,Freychet P. Effect of feeding and fasting on the early steps of glucagons action in isolated rat liver cells[J]. Endocrinology , 1999, 98 (3) : 755-760.
[10]刘靖,陆大祥.甘氨酸对高脂饮食诱导小鼠高脂血症的保护作用[J].实用肝脏杂志,2010,13(4):256-259.
[11]肖美添,叶静.江蓠藻膳食纤维降血脂作用研究[J].食品科学,2010,31(11):241-243.
[12]朱立贤,金证宇.白藜芦醇对大鼠实验性高脂血症的影响[J].食品科学,2005,26(10):228-230.
[13]Liaw YF,Leung NW，Chang TT,et a1．Effects of extended lamivudine therapy in Asian patients with chronic hepatitisAsia Hepatitis Lamivudine Study Group [J]．Gastroenterology,2000,119:172—180.
[14]田春元,周秀佳.鹰嘴豆种子水煎剂对高脂血症大鼠血脂含量影响的实验研究[J].食品科学,2010,31(1): 232-235.
[15]Leung NW.Extended lamivudine treatment in patients with chronic hepatitis Benchances hepatitis Be antigen seroconvemion rates：results after three years of therapy[J]．Hepatology,2001,33:1527—1532.
[16] Cheng HH，Lai MH. Fermentation of resistant rice starch produces propionate reducing serum and hepatic cholesterol in rats[J]. Nutr, 2000, 130:1991－1995.
[17] De Deckere EA, Pentieva K, McKillop D, et al. Acute absorption of folic acid from a fortified low-fat spread[J]. Eur J Clin Nutr, 2003, 57:1235－1241.
[18].张文青,张月明.抗性淀粉对大鼠肝脏胆固醇代谢相关基因表达的影响[J].营养学报.2007,29(5):458-461.