食品科学 ›› 2010, Vol. 31 ›› Issue (5): 288-292.doi: 10.7506/spkx1002-6300-201005065

• 营养卫生 • 上一篇    下一篇

自制酸奶乳脂中c9,t11-共轭亚油酸对小鼠免疫调节作用的影响

王璇琳1,檀英霞1,郁成雨1,李素波1,贺 敏1,李伟静1,陈炳卿2,于 群1 ,*   

  1. 1.北京军事医学科学院野战输血研究所 2.哈尔滨医科大学公共卫生学院
  • 收稿日期:2009-04-23 出版日期:2010-03-01 发布日期:2010-12-29
  • 通讯作者: 于 群 E-mail:yuq@nic.bmi.ac.cn

Immunoregulatory Effect of Laboratory Prepared Yogurt containing c9, t11- Conjugated Linoleic Acid in Mice

WANG Xuan-lin1,TAN Ying-xia1,YU Cheng-yu1,LI Su-bo1,HE Min1,LI Wei-jing1,CHEN Bing-qing2,YU Qun1,*   

  1. 1. Beijing Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850, China;
    2. College of Public Health, Harbin Medical University, Harbin 150086, China
  • Received:2009-04-23 Online:2010-03-01 Published:2010-12-29
  • Contact: YU Qun E-mail:yuq@nic.bmi.ac.cn

摘要:

应用乳酸菌发酵法,添加适当底物和营养物质,实验室自制含共轭亚油酸(CLA)的酸奶,经过提取乳脂、气相色谱检测并对CLA 定量后,确定给予小鼠受试物剂量组,进行共轭亚油酸酸奶的免疫调节功能实验。结果表明:灌胃给予小鼠含0.05g/(kg bw·d) c9,t11-CLA 的乳脂,30d 后可增强小鼠的免疫调节功能,说明酸奶中的c9,t11-CLA 能够显著增加小鼠免疫调节能力。

关键词: 乳酸菌发酵, 共轭亚油酸, 乳脂, 免疫调节

Abstract:

A yogurt with c9, t11-conjugated linoleic acid (CLA) was prepared by adding suitable substrate and nutrients to milk for Lactobacillus fermentation. Milk fat was extracted and CLA was quantitatively determined by gas chromatography to design the administration dosage and study the immunoregulatory function of CLA in mice. Results indicated that the administration of CLA at a dose of 0.05 g/kg bw·d for 30 consecutive days could significantly enhance immunoregulatory function in mice. This fact demonstrates an excellent immunoregulatory effect of CLA in mice.

Key words: Lactobacillus fermentation, c9, t11-conjugated linoleic acid (CLA), milk fat, immunoregulation

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