刺五加苷对半乳糖亚急性衰老模型大鼠的影响

doi:10.7506/spkx1002-6630-200915047

食品科学 ›› 2009, Vol. 30 ›› Issue (15): 205-207.doi: 10.7506/spkx1002-6630-200915047

刺五加苷对半乳糖亚急性衰老模型大鼠的影响

孟宪军¹，杨平^1,2，张春红¹

1.沈阳农业大学食品学院 2.辽宁省基础医学研究所

收稿日期:2009-03-03 修回日期:2009-05-07 出版日期:2009-08-01 发布日期:2010-12-29
通讯作者: 孟宪军 E-mail:JQIAO666@163.COM
基金资助:
辽宁省自然科学基金项目(2006301031)

Effect of Ciwujia Glycosides on D-Galactose-induced Subacute Intoxicating Rats

MENG Xian-jun1，YANG Ping1,2，ZHANG Chun-hong1

1. College of Food Science, Shenyang Agricultural University, Shenyang 110161, China；
2. Liaoning Institute for Medical Research Foundation, Shenyang 110101, China

Received:2009-03-03 Revised:2009-05-07 Online:2009-08-01 Published:2010-12-29
Contact: MENG Xian-jun E-mail:JQIAO666@163.COM

摘要/Abstract

摘要：

目的：研究刺五加苷(CG)对半乳糖亚急性衰老模型大鼠的影响。方法：用D- 半乳糖(D-gal)造成大鼠亚急性衰老模型，CG 按3.6、7.2、14.4g/kg bw·d 连续灌胃，检测大鼠的脏器指数，测定T 淋巴细胞增殖功能，组织中超氧化物歧化酶(SOD)活力、丙二醛(MDA)浓度，血清IL-2(IL-2)、白介素-6(IL-6)浓度。结果：CG 能明显提高衰老模型大鼠胸腺指数和T 淋巴细胞增殖功能，增强组织SOD 活性，降低组织MDA 浓度，提高血清IL-2 浓度，降低血清IL-6 浓度。结论：CG 可以清除亚急性衰老模型大鼠的自由基和改善免疫系统。

关键词: 刺五加苷, 亚急性衰老模型, 丙二醛, 超氧化物歧化酶, 白介素-2, 白介素-6

Abstract:

Objective: To explore the effect of Ciwujia glycosides on D-galactose-induced subacute intoxicating rats. Methods: Subacute intoxication models of rats were constructed by administering them with 100 mg/(kg bw·d) of D-galactose through intraperitoneal injection. Healthy SD rates were randomly divided into 5 groups of 8 rate each (half female and half male): control group, subacute intoxication model group, and low-, medium- and high-dose-treated groups administered with 3.6, 7.2, and 14.4 g/(kg bw·d) of Ciwujia glycosides by gavage, respectively. After continued administration for 8 weeks, all the rats were sacrificed, and then the thymus index and spleen index were measured and the proliferation capability of T lymphocyte, tissue SOD activity and MDA concentration, and serum interleukin-2 (IL-2) and interleukin-6 (IL-6) concentrations were assayed. Results: Pronounced rises in thymus index, proliferation capability of T lymphocyte, tissue SOD activity and serum IL-2 concentration and falls in tissue MDA concentration and serum IL-6 concentration were observed in Ciwujia glycosides-treated rats in comparison with subacute intoxicating ones. Conclusion: Ciwujia glycosides can effectively scavenge free radicals and improve the immune system in D-galactose induced subacute intoxicating rats.

Key words: Ciwujia glycosides, subacute intoxicating rats, malondialdehyde (MDA), superoxidedismutase (SOD), IL-2, IL-6

中图分类号:

Q539

孟宪军1，杨平1,2，张春红1. 刺五加苷对半乳糖亚急性衰老模型大鼠的影响[J]. 食品科学, 2009, 30(15): 205-207.

MENG Xian-jun1，YANG Ping1,2，ZHANG Chun-hong1. Effect of Ciwujia Glycosides on D-Galactose-induced Subacute Intoxicating Rats[J]. FOOD SCIENCE, 2009, 30(15): 205-207.

[1]	蒋祎人，李涛，刘友明，熊善柏. 丙二醛氧化修饰对白鲢肌原纤维蛋白结构性质的影响[J]. 食品科学, 2020, 41(6): 1-7.
[2]	陈聪聪，王新伟，赵仁勇. 不同加工精度小麦粉储藏过程中脂类变化规律[J]. 食品科学, 2020, 41(3): 159-164.
[3]	陈亚婷, 韩祥稳, 周游, 曹崇江. 乙烯利复合包装材料对香蕉后熟品质的影响[J]. 食品科学, 2020, 41(15): 262-268.
[4]	孙世旭，李莉，韩祥稳，周游，曹崇江. 纳米抗菌包装材料对延缓白莲藕风味品质劣变的影响[J]. 食品科学, 2019, 40(7): 212-218.
[5]	沈鹏辉，樊诗堃，赵谋明，周非白. 氧化对大豆蛋白结构、乳液稳定性及消化特性的影响[J]. 食品科学, 2019, 40(14): 7-14.
[6]	周麟依，孙玉凤，吴非. 丙二醛氧化对米糠蛋白结构及功能性质的影响[J]. 食品科学, 2019, 40(12): 98-107.
[7]	田勇，周督，邹双忆，孙星宇，郅琦，李福香，明建. 昆仑雪菊水溶性黄酮提取物对D-半乳糖致衰老小鼠学习记忆障碍的改善作用[J]. 食品科学, 2019, 40(1): 162-168.
[8]	高原，王福玲，贾琦，刘微，周艳岩，张晓萌，咸玥桐. 降香内生真菌代谢产物对H2O2诱导的HepG2细胞氧化损伤保护作用[J]. 食品科学, 2018, 39(11): 196-200.
[9]	董雪临，张超，马越，赵晓燕. 运输振动对鲜切生菜品质的影响[J]. 食品科学, 2016, 37(8): 255-259.
[10]	陈蓉1，刘俊1，徐卫红1,*，谢文文1，熊仕娟1，张进忠1，熊治庭2，焦文涛3. 外源镧对不同品种黄瓜镉积累及镉化学形态的影响[J]. 食品科学, 2015, 36(5): 38-44.
[11]	张丽媛1，马红丹1，赵邯郸1，徐丹丹1，曲静2，关淑艳1,，王丕武2,. 利用低温聚合酶链式反应技术提高大豆超氧化物歧化酶活性[J]. 食品科学, 2015, 36(5): 126-130.
[12]	黄雅琴，李尽哲，段鸿斌，殷东林. 蛹虫草对紫外诱导果蝇氧化损伤的保护作用[J]. 食品科学, 2015, 36(21): 258-262.
[13]	李梅青1,2，张瑜1，代蕾莉1，孔祥淋1，杜晓妹1. Plackett-Burman试验设计及响应面法优化超声辅助提取明绿豆SOD工艺[J]. 食品科学, 2015, 36(2): 69-74.
[14]	熊博，汪志辉*，高婧斐，张婷婷，石冬冬，古咸杰，曾海琼，廖玲. 外源亚精胺对黄果柑果实抗氧化酶活性的影响[J]. 食品科学, 2015, 36(10): 245-248.
[15]	马红丹1，张丽媛1，赵邯郸1，徐丹丹1，曲静2，关淑艳1,，王丕武2,. 大豆锰超氧化物歧化酶基因在乳酸乳球菌中的分泌表达[J]. 食品科学, 2015, 36(1): 135-139.

刺五加苷对半乳糖亚急性衰老模型大鼠的影响

Effect of Ciwujia Glycosides on D-Galactose-induced Subacute Intoxicating Rats

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价