食品科学 ›› 2005, Vol. 26 ›› Issue (10): 211-213.

• 营养卫生 • 上一篇    下一篇

大豆异黄酮抗氧化效能的研究

 李国莉, 杨建军, 任彬彬, 刘贺荣, 赵伟明, 张居慧, 刘瑛   

  1. 宁夏医学院营养与食品卫生学教研室
  • 出版日期:2005-10-15 发布日期:2011-09-25

Studies of Soy Isoflavones on Antioxidation

 LI  Guo-Li, YANG  Jian-Jun, REN  Bin-Bin, LIU  He-Rong, ZHAO  Wei-Ming, ZHANG  Ju-Hui, LIU  Ying   

  1. Department of Nutrition and Food Hygienic, Ningxia Medical College
  • Online:2005-10-15 Published:2011-09-25

摘要: 目的:观察大豆异黄酮对小鼠抗氧化效能的影响。方法:选用BALB/C雄性小鼠60只,体重18~22g,随机分为4组:空白对照组、低剂量组、中剂量组和高剂量组,空白对照组喂饲基础饲料,其余3组分别喂饲添加25、100、200mg/kg大豆异黄酮的基础饲料。实验第8周末,将小鼠断头处死,取血、心脏、肝脏组织测定SOD、GSH-Px、CAT、MDA、H2O2和T-AOC等指标。结果:与空白对照组比较,小鼠肝脏中的MDA和H2O2含量显著降低(p<0.01),小鼠全血和肝脏、心脏GSH-Px和CAT活性明显升高(p<0.01),肝脏、心脏SOD活性,T-AOC含量明显升高(p<0.01)。结论:大豆异黄酮具有明显的抗氧化作用。

关键词: 大豆异黄酮, 抗氧化, 自由基

Abstract: Objective: To investigate the antioxidation effects of soy isoflavones in mice during an experimental period of 8 weeks. Methods: 60 BALB/C male mice (18~22g , BW) were divided randomly into 4 groups and fed a basal diet supplemented with 25,100, 200mg/kg soy isoflavones. Results:The MDA and H2O2 levels in liver were significantly lower than those of the control group (p<0.01). The GSH-Px and CAT activities of in liver and whole blood were increased obviously (p<0.01). The SOD, T-AOC levels in liver were significantly increased (p<0.01). Conclusion: These results suggested that soy isoflavones can improve the ability of antioxidation obviously.

Key words: soy isoflavones, anti-oxidation, free radical