Abstract:

To examine the potential hypolipidemic and antioxidant effects of flavonoids from sea buckthorn (Hippophae rhamnoides L.) pomace (SBPF) in ICR mice with diabetes, healthy IR mice were used as experimental animals to create an alloxan (ALX) induced diabetic model. Mice with ALX induced diabetes were randomly divided into 4 groups including model control group administered normal saline by gavage and SBPF groups administered low, medium and high doses of SBPF aqueous solution at the same volume as normal saline by gavage. Additional healthy IR mice were served as normal control group and also administered normal saline by gavage like the model control group. All the groups were administered once a day for 4 consecutive weeks. Results showed that compared with the model control group, the three SBPF groups exhibited significantly lowered serum glucose, blood liquid, MDA and BUN levels, elevated insulin and glycogen levels and SOD, GSH-PX and CAT activities, and enhanced antioxidant function and diet level. In conclusion, SBPF administration not only effectively regulates the levels of serum glucose and blood lipid, but also enhances antioxidant function in diabetic mice.

Key words: flavonoids from sea buckthorn (Hippophae rhamnoides L.) pomace (SBPF), diabetes, serum glucose, blood lipid, antioxidant function