FOOD SCIENCE ›› 2013, Vol. 34 ›› Issue (11): 386-391.doi: 10.7506/spkx1002-6630-201311080
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LIU Wei，ZHOU Jie，GONG Zheng-li*
Received:2012-03-21
Revised:2013-05-02
Online:2013-06-15
Published:2013-06-03
CLC Number:
LIU Wei，ZHOU Jie，GONG Zheng-li*. Research Progress in Functional Activity of Theaflavins[J]. FOOD SCIENCE, 2013, 34(11): 386-391.
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URL: https://www.spkx.net.cn/EN/10.7506/spkx1002-6630-201311080
| [1] ROBERTS E A H. The phenolic substances of manufactured tea(I)[J]. Journal of the Science of Food and Agriculture, 1957, 8(2): 72-80.[2] 杨贤强, 王岳飞, 陈留记. 茶多酚化学[M]. 上海: 上海科学技术出版社, 2003: 88-92.[3] 宛晓春. 茶叶生物化学[M]. 3版. 北京: 中国农业出版社, 2003:181-184.[4] 丁阳平, 刘仲华, 黄建安. 聚酰胺分离纯化茶黄素类物质研究[J]. 食品科学, 2007, 28(12): 55-57.[5] YANG C J, LI D X, WAN X C. Combination of HSCCC and Sephadex LH-20 methods-an approach to isolation and purification of the main individual theaflavins from black tea[J]. Journal of Chromatography B, 2008, 861(1): 140-144.[6] WANG K B, LIU Z H, HUANG J A, et al. Preparative isolation and purification of theaflavins and catechins by high-speed countercurrent chromatography[J]. Journal of Chromatography B, 2008, 867(2): 282-288.[7] 王坤波, 刘仲华, 黄建安, 等. 高速逆流色谱法分离茶黄素条件的优化[J]. 食品科学, 2009, 30(6): 191-195.[8] 张建勇, 江和源, 崔宏春, 等. 4种主要茶黄素单体分离制备方法研究进展[J]. 食品科学, 2009, 30(23): 493-497.[9] 黄永东, 江用文, 江和源, 等. 模拟移动床色谱及其在茶叶功能成分分离中的应用前景[J]. 食品科学, 2011, 32(15): 296-302.[10] RICE-EVANS C A, MILLER N J, PAGANGA G. Structure-antioxidant activity relationships of flavonoids and phenolic acids[J]. Free Radic Boil Med, 1996, 20(7): 933-956.[11] Saha P, Das S. Regulation of hazardous exposure by protective exposure：modulation of phaseⅡdetoxification and lipid peroxidation by camellia sinensis and swertia chirata[J]. Teratogenesis, Carcinogenesis and Mutagenesis Supplement, 2003(1): 313-322.[12] DEGUCHI M, NISHIMURA M, ISHIYAMA K, et al. Detection of methylated theaflavin derivatives in black tea leaves and their antioxidant properties[J]. Yakugaku Zasshi-Journal of the Pharmaceutical Society of Japan, 2007(127): 143-144.[13] YANG Z Y, JIE G L, DONG F, et a1. Radical-scavenging abilities and antioxidant properties of theaflavins and their gallate esters in H2O2-mediated oxidative damage system in the HPF-1 cells[J]. Toxicology in Vitro, 2008, 22(5): 1250-1256.[14] LI B, VIK S B, TU Y Y. Theaflavins inhibit the ATP synthase and the respiratory chain without increasing superoxide production[J]. Journal of Nutritional Biochemistry, 2011(127): 143-144.[15] JIANG H Y, HANG X, YUAN X Y, et a1. Anticancer Activity of Theaflavin Diagallate and its Mechanism[J]. Journal of Tea Science, 2007, 27(1): 33-38.[16] BABICH H, PINSKY S M, MUSKIN E T, et a1. In vitro cytotoxicity of a theaflavin mixture from black tea to malignant, immortalized, and normal cells from the human oral cavity[J]. Toxicology in Vitro , 2006, 20(5): 677-688.[17] BABICH H, GOTTESMAN R T, LIEBLING E J, et a1. Theaflavin-3-gallate and theaflavin-3'-gallate, polyphenols in black tea with prooxidant properties[J]. Basic & Clinical Pharmacology & Toxicology, 2008, 103(1): 66-74.[18] SCHUCK A G, AUSUBEL M B, ZUCKERBRAUN H L, et a1. Theaflavin-3,3'-digallate, a component of black tea: An inducer of oxidative stress and apoptosis[J]. Toxicology in Vitro, 2008, 22(3): 598-609.[19] MIZUNO H, CHO Y Y, ZHU F, et a1. Theaflavin-3,3'-digallate induces epidermal growth factor receptor downregulation[J]. Molecular Carcinogenesis, 2006, 45(3): 204-212.[20] LU J B, GOSSLAU A, LIU A Y C, et a1. PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate[J]. European Journal of Pharmacology, 2008, 601(1-3): 66-72.[21] PRASAD S, KAUR J, ROY P, et a1. Theaflavins induce G2/M arrest by modulating expression of p21waf1/cip1, cdc25C and cyclin B in human prostate carcinoma PC-3 cells[J]. Life Sciences, 2007(81): 1323-1331.[22] SIL H, SEN T, MOULIK S, et a1. Black Tea Polyphenol (Theaflavin) Downregulates MMP-2 in Human Melanoma Cell Line A375 by Involving Multiple Regulatory Molecules[J]. Journal of Environmental Pathology Toxicology and Oncology, 2010, 29(1): 55-68.[23] SENGUPTA A, GHOSH S, DAS R K, et a1. Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways[J]. European Journal of Cancer Prevention, 2006, 15(4): 301-305.[24] LAHIRY L, SAHA B, Chakraborty J, et a1. Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis[J]. Apoptosis, 2008, 13(6): 771-781.[25] GOSSLAU A, JAO D L E, HUANG M T, et a1. Effects of the black tea polyphenol theaflavin-2 on apoptotic and inflammatory pathways in vitro and in vivo[J]. Molecular Nutrition & Food Research, 2011, 55(2): 198-208.[26] HALDER B, PRAMANICK S, MUKHOPADHYAV S, et a1. Anticlastogenic effects of black tea polyphenols theaflavinsand thearubigins in human lymphocytes in vitro[J]. Toxicology in Vitro, 2006(20): 608-613.[27] TODA M, OKUBO S, HARA Y, et a1. Antibacterial and bactericidal activities of tea extracts and catechins against methicillin resistant Staphylococcus aureus [J]．Nippon Saikingaku Zasshi, 1991, 46(5): 839-845.[28] YAMT S, SHAH S, HAMILTON M. Microbiological activity of whole and fractionated crude extraets of tea(Camellia sinensis)and of tea components[J]. FEMS Microbiology Letters, 1997, 152(1): 169-174.[29] FRIEDMAN M, HENIKA P R, LEVIN C E, et a1. Antimicrobial activities of tea catechins and theaflavins and tea extracts against Bacillus cereus[J]．Journal of Food Protection, 2006, 69(2): 354-361.[30] BETTS J W, KELLY S M, HASWELL S J. Antibacterial effects of theaflavin and synergy with epicatechin against clinical isolates of Acinetobacter baumannii and Stenotrophomonas maltophilia[J]. International Journal of Antimicrobial Agents, 2011, 38(5): 421-425.[31] CHEN C N, LIN P C, HUANG K K, et a1. Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3, 3-digallate (TF3)[J]．Evidence-Based Complementary and Alternative Medicine: eCAM, 2005, 2(2): 209-215.[32] LIU S W, LU H, ZHAO Q, et a1. Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41 [J]. Biochimica Et Biophysica Acta-General Subjects, 2007, 1770(2): 312-312.[33] YANG J, LI L, TAN S Y, et a1. A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: Potential applications for preventing HIV-1 infection[J]. Fitoterapia, 2012, 83(2): 348-355.[34] UKIL A, MAITY S, DAS P K. Protection from experimental colitis by theaflavin-3,3 '-digallate correlates with inhibition of IKK and NF-kappa B activation[J]. British Journal of Pharmacology, 2006, 149(1):121-131.[35] HOSOKAWA Y, HOSOKAWA I, SHINDO S, et a1. Black tea polyphenol inhibits CXCL10 production in oncostatin M-stimulated human gingival fi broblasts[J]. International Immunopharmacology, 2011(11): 670-674.[36] HUANG M T, LIU Y, RAMJI D, et a1. Inhibitory effects of black tea theaflavin derivatives on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and arachidonic acid metabolism in mouse ears[J]. Molecular Nutrition & Food Research, 2006, 50(2): 115-122.[37] WANG H X, SUN J T, LV W P, et a1. Research Progress on Preparation, Analysis, Separation and Function of Theaflavins[J]. Journal of Food Science and Biotechnology, 2011, 30(1): 12-19.[38] MA H J, MA H J, LI Q, et a1. Effect of theaflavin on intracellular free calcium concentration in rat ventricular myocytes[J]. Chinese Pharmacological Bulletin, 2009, 25(8): 1032-1035.[39] VERMEER M A, MULDER T P J, MOLHUIZEN H O F. Theaflavins from Black Tea, Especially Theaflavin-3-gallate, Reduce the Incorporation of Cholesterol into Mixed Micelles[J]. Journal of Agricultural and Food Chemistry, 2008, 56(24): 12031-12036.[40] DREGER H, LORENZ M, KEHRER A, et a1. Characterisics of catechin- and theaflavin-mediated cardioprotection[J]. Experimental Biology and Medicine, 2008, 233(4): 427-433.[41] CAI F, LI C R, WU J L, et a1. The anti-inflammatory effect of theaflavin on focal ischemia-reperfusion injury in Rats[J]. Pharmacology and Clinics of Chinese Materia Medica, 2007, 23(1): 23-24.[42] CAI F, LI C R, WU J L, et a1. The Protective Effect of Theaflavin on Focal Ischemia- reperfusion Injury in Rats[J]. Lishizhen Medicine and Materia Medica Research, 2008, 19(6): 1396-1398.[43] CAI F, LI C R, WU J L, et a1. Modulation of the oxidative stress and nuclear factor kappa B activation by theatlavin 3,3 '-gallate in the rats exposed to cerebral ischemia-reperfusion[J]. Folia Biologica, 2007, 53(5): 164-172.[44] SKRZYPCZAK-JANKUN E, JANKUN J. Theaflavin digallate inactivates plasminogen activator inhibitor: Could tea help in Alzheimer's disease and obesity?[J]. International Journal of Molecular Medicine, 2010, 26(1): 45-50.[45] ANANDHAN A, TAMILSELVAM K, RADHIGA T, et a1. Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease[J]. Brain Research, 2012(1433): 104-113.[46] NISHIKAWA T, ARAKI E. Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications[J]. Antioxid Redox Signal, 2007, 9(3): 343-353. [47] THALLAS-BONKE V, THORPE S R, COUGHLAN M T, et al. Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway[J]. Diabetes, 2008, 57(2): 460-469. [48] SAKAI N, WADA T, FURUICHI K, et al. Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy[J]. Am J Kidney Dis, 2005, 45(1): 54-65.[49] LI C R, CAI F, ZHAO X Y, et al. Effect of Theaflavin on the Activity of p38 Mitogen-activated Protein Kinase (p38MAPK) and Extracellar Matrix Production in Rat Mesangial Cells[J]. Journal of Tea Science, 2009, 29(6): 470-474.[50] ARENT S M, SENSO M, GOLEM D L, et al. The effects of theaflavin-enriched black tea extract on muscle soreness, oxidative stress, inflammation, and endocrine responses to acute anaerobic interval training: a randomized, double-blind, crossover study[J]. Journal of the International Society of Sports Nutrition, 2010, 7(1): 11.[51] LUO X Y, TAKAHARA T, HOU J G, et a1. Theaflavin attenuates ischemia–reperfusion injury in a mouse fatty liver model[J]. Biochemical and Biophysical Research Communications, 2012(417): 287-293.[52] 刘冬英, 王茵. 茶叶多酚心血管保护作用的分子机制研究进展[J]. 食品科学, 2011, 31(21): 464-468. |
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