Abstract:

Objective: To study the effect of abscisic acid (ABA) in fructose-induced insulin resistant mice. Methods: All male
mice were divided randomly into six groups, including normal control, model, positive control (pioglitazone hydrochloride,
15 mg/(kg·d), and high-dose (3 mg/(kg·d)), medium-dose (1.5 mg/(kg·d)) and low-dose (0.75 mg/(kg·d)) ABA groups
(n =10). Except for the control group, the mice from all the groups were administrated with 10% fructose in drinking water
for 30 consecutive days. At the end of the experiment, all mice were sacrificed. Blood samples were collected to evaluate
glucose, insulin and blood lipid. The contents of muscle glycogen and liver glycogen were determined as well. Results:
Fructose could significantly increase fasting serum glucose concentration and serum insulin concentration. After 30 days
of administration, high-dose, medium-dose and low-dose ABA could significantly reduce serum glucose and insulin
concentrations, and increase muscle glycogen and liver glycogen contents; medium- and high-dose ABA could significantly
reduce serum triglyceride and cholesterol levels, and improve high-density lipoprotein cholesterol level. Conclusion: The
middle-dose and high-dose ABA can significantly improve insulin sensitivity in mice, implying a good intervention effect on
insulin resistance. Its effect is better than that of pioglitazone.

Key words: abscisic acid, fructose, insulin resistance